Iron(II) Chloride Catalyzed Ligand-Free Double Carbonylation of o-Diiodoarenes with Anilines: A Novel Synthetic Approach to Phthalimide Derivatives

Sarma V. Markandeya; Gandham Hima Bindu; Chidara Sridhar; B. Venkateswara Rao

doi:10.14233/ajchem.2025.34760

Issue

Vol. 37 No. 10 (2025): Vol 37 Issue 10, 2025

Issue Published : 30 September 2025

This work is licensed under a Creative Commons Attribution 4.0 International License.

Iron(II) Chloride Catalyzed Ligand-Free Double Carbonylation of o-Diiodoarenes with Anilines: A Novel Synthetic Approach to Phthalimide Derivatives

https://doi.org/10.14233/ajchem.2025.34760

Sarma V. Markandeya

Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad-500076, India; Department of Engineering Chemistry, Andhra University, Visakhapatnam-530003, India

https://orcid.org/0009-0002-6044-3201

Gandham Hima Bindu

Department of Engineering Chemistry, Andhra University, Visakhapatnam-530003, India

https://orcid.org/0000-0003-1623-6563

Chidara Sridhar

Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad-500076, India

https://orcid.org/0000-0002-0122-4589

B. Venkateswara Rao

Department of Engineering Chemistry, Andhra University, Visakhapatnam-530003, India

https://orcid.org/0000-0002-4960-2892

Corresponding Author(s) : Gandham Hima Bindu

himabinduauce@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 10 (2025): Vol 37 Issue 10, 2025
Article Published : 30 September 2025

Abstract

Herein, an iron-catalyzed, ligand-free method for the double carbonylation of ortho-diiodoarenes with anilines in the presence of carbon monoxide is reported. This protocol proceeds efficiently, affording N-substituted phthalimides with excellent selectivity and high yields. The results highlight a novel and sustainable synthetic approach to phthalimide derivatives, underscoring the potential of iron catalysis in heterocycle construction.

Keywords

Amino carbonylation Carbon monoxide Iron(II) chloride o-Diiodoarenes Phthalimides

(1)

Markandeya, S. V.; Bindu, G. H.; Sridhar, C.; Rao, B. V. Iron(II) Chloride Catalyzed Ligand-Free Double Carbonylation of O-Diiodoarenes With Anilines: A Novel Synthetic Approach to Phthalimide Derivatives. ajc 2025, 37, 2612-2616.

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