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Vol. 37 No. 11 (2025): Vol 37 Issue 11, 2025

Copyright (c) 2025 Sayana K V, Manoj, Vishwanath T

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Development of Novel Caffeine-Loaded Polyvinyl Alcohol Nanofabric Face Wipe: A Comparative Electrochemical Release Profiling using Bare and Modified Electrodes

https://doi.org/10.14233/ajchem.2025.34658
K.V. Sayana
Department of Materials Science, Mangalore University, Mangalore-574199, India
https://orcid.org/0009-0006-4451-5518
Manoj Hebri
Department of Materials Science, Mangalore University, Mangalore-574199, India
https://orcid.org/0000-0002-7756-3472
T. Vishwanath
Department of Materials Science, Mangalore University, Mangalore-574199, India
https://orcid.org/0000-0001-7631-8806

Corresponding Author(s) : T. Vishwanath

vishutcg@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 11 (2025): Vol 37 Issue 11, 2025

Abstract

This study presents the preparation and electrochemical evaluation of a novel caffeine-infused nanofabric designed for controlled topical delivery. The caffeine-infused PVA nanofabric was prepared using electrospinning technique and characterized by spectral and analytical methods. The nanofabric was formulated to gradually release caffeine upon wetting and the release profile was monitored at different time intervals. Quantification of the released caffeine was carried out using linear sweep voltammetry (LSV), employing both a bare glassy carbon electrode (GCE) and a modified GCE (MGCE) fabricated by electrospinning a nanocomposite of polyvinyl alcohol (PVA), Multiwalled carbon nanotubes (MWCNT) and graphene oxide (GO). Calibration curves using standard caffeine solutions demonstrated excellent linearity for both electrodes, with enhanced sensitivity, especially observed in MGCE (R2 = 0.999) compared to the GCE (R2 = 0.997). The modified electrode also exhibited lower limits of detection (LOD = 0.042 mg/mL) and quantification (LOQ = 0.139 mg/mL), confirming its superior analytical performance. Cyclic voltammetry (CV) at varying scan rates revealed a purely diffusion-controlled process for GCE, while the modified electrode indicated a mixed diffusion-adsorption mechanism. The maximum release of caffeine from the wipe was achieved at 30 min, establishing its efficiency as a sustained-release skincare application. This work also highlights the potential of combining electrospun nanofiber-modified electrodes with electrochemical techniques for evaluating the performance of face wipe fabric.

Keywords

Caffeine Electrospinning Electrochemical sensor Polyvinyl alcohol Face wipe
(1)
Sayana, K.; Hebri, M.; Vishwanath, T. Development of Novel Caffeine-Loaded Polyvinyl Alcohol Nanofabric Face Wipe: A Comparative Electrochemical Release Profiling Using Bare and Modified Electrodes. ajc 2025, 37, 2855-2864.
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