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Vol. 31 No. 8 (2019): Vol 31 Issue 8

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Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery

https://doi.org/10.14233/ajchem.2019.21941
Nguyen Thi Thanh Thuy
Department of Chemistry, Nong Lam University, Ho Chi Minh City, Vietnam
Le Duc Anh
Department of Chemistry, Nong Lam University, Ho Chi Minh City, Vietnam
Nguyen Huu Tri
Department of Natural Resources and Environment, Dong Nai Province, Vietnam
Cu Van Hoang
Department of Chemistry, Nong Lam University, Ho Chi Minh City, Vietnam
Nguyen Anh Nhut
Department of Chemistry, Nong Lam University, Ho Chi Minh City, Vietnam

Corresponding Author(s) : Nguyen Thi Thanh Thuy

nguyenthanhthuy@hcmuaf.edu.vn

Asian Journal of Chemistry, Vol. 31 No. 8 (2019): Vol 31 Issue 8

Abstract

The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.

Keywords

Curcumin Iron oxide nanoparticles Polyethylene glycol Response surface methodology Sonication
Thanh Thuy, N. T., Anh, L. D. ., Tri, N. H., Hoang, C. V., & Nhut, N. A. (2019). Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery. Asian Journal of Chemistry, 31(8), 1719–1723. https://doi.org/10.14233/ajchem.2019.21941
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