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Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery
Corresponding Author(s) : Nguyen Thi Thanh Thuy
Asian Journal of Chemistry,
Vol. 31 No. 8 (2019): Vol 31 Issue 8
Abstract
The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.
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References
A.H. Lu, E.L. Salabas and F. Schüth, Angew. Chem. Int. Ed., 46, 1222 (2007); https://doi.org/10.1002/anie.200602866.
C. Yang, A. Rait, K.F. Pirollo, J.A. Dagata, N. Farkas and E.H. Chang, Nanomed.-Nanotechnol., 4, 318 (2008); https://doi.org/10.1016/j.nano.2008.05.004.
Y. Ling, K. Wei, Y. Luo, X. Gao and S. Zhong, Biomaterials, 32, 7139 (2011); https://doi.org/10.1016/j.biomaterials.2011.05.089.
Z.-Q. Zhang and S.-C. Song, Biomaterials, 106, 13 (2016); https://doi.org/10.1016/j.biomaterials.2016.08.015.
C. Saikia, M.K. Das, A. Ramteke and T.K. Maji, Int. J. Biol. Macromol., 93, 1121 (2016); https://doi.org/10.1016/j.ijbiomac.2016.09.043.
A. Mashhadi Malekzadeh, A. Ramazani, S.J. Tabatabaei Rezaei and H. Niknejad, J. Colloid Interface Sci., 490, 64 (2017); https://doi.org/10.1016/j.jcis.2016.11.014.
S. Theerdhala, D. Bahadur, S. Vitta, N. Perkas, Z. Zhong and A. Gedanken, Ultrason. Sonochem., 17, 730 (2010); https://doi.org/10.1016/j.ultsonch.2009.12.007.
L. Ngaboni Okassa, H. Marchais, L. Douziech-Eyrolles, S. Cohen-Jonathan, M. Soucé, P. Dubois and I. Chourpa, Int. J. Pharm., 302, 187 (2005); https://doi.org/10.1016/j.ijpharm.2005.06.024.
B.R. Jarrett, M. Frendo, J. Vogan and A.Y. Louie, Nanotechnology, 18, 035603 (2007); https://doi.org/10.1088/0957-4484/18/3/035603.
L. Li, D. Chen, Y. Zhang, Z. Deng, X. Ren, X. Meng, F. Tang, J. Ren and L. Zhang, Nanotechnology, 18, 405102 (2007); https://doi.org/10.1088/0957-4484/18/40/405102.
M. Mahmoudi, A. Simchi, M. Imani, A.S. Milani and P. Stroeve, J. Phys. Chem. B, 112, 14470 (2008); https://doi.org/10.1021/jp803016n.
A. Masoudi, H.R. Madaah Hosseini, M.A. Shokrgozar, R. Ahmadi and M.A. Oghabian, Int. J. Pharm., 433, 129 (2012); https://doi.org/10.1016/j.ijpharm.2012.04.080.
M. Mahmoudi, A. Simchi, A. Milani and P. Stroeve, J. Colloid Interface Sci., 336, 510 (2009); https://doi.org/10.1016/j.jcis.2009.04.046.
C. Araujo and L. Leon, Mem. Inst. Oswaldo Cruz, 96, 723 (2001); https://doi.org/10.1590/S0074-02762001000500026.
K.K. Cheng, P.S. Chan, S. Fan, S.M. Kwan, K.L. Yeung, Y.-X.J. Wang, A.H.L. Chow, E.X. Wu and L. Baum, Biomaterials, 44, 155 (2015); https://doi.org/10.1016/j.biomaterials.2014.12.005.
R. Konwarh, J.P. Saikia, N. Karak and B.K. Konwar, Colloid Surf. B, 81, 578 (2010); https://doi.org/10.1016/j.colsurfb.2010.07.062.
S. García-Jimeno and J. Estelrich, Colloid Surf. A, 420, 74 (2013); https://doi.org/10.1016/j.colsurfa.2012.12.022.
B. Cullity and S. Stock, Elements of X-Ray Diffraction, Upper Saddle River, NJ: Prentice Hall, edn 3 (2001).
R. Ahmadi, M. Malek, H.R.M. Hosseini, M.A. Shokrgozar, M.A. Oghabian, A. Masoudi, N. Gu and Y. Zhang, Mater. Chem. Phys., 131, 170 (2011); https://doi.org/10.1016/j.matchemphys.2011.04.083.
A.K. Gupta and S. Wells, IEEE T. Nanobiosci., 3, 66 (2004); https://doi.org/10.1109/TNB.2003.820277.