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Vol. 27 No. 2 (2015): Vol 27 Issue 2

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Synthesis of 1,5-Benzodiazepine Derivatives Using p-Toluenesulfonic Acid as Catalyst

https://doi.org/10.14233/ajchem.2015.16927
Shasha Wang
College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P.R. China *Corresponding author: E-mail: wanglanzhi@126.com
Lijuan Hu
College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P.R. China *Corresponding author: E-mail: wanglanzhi@126.com
Suyan Cheng
College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P.R. China *Corresponding author: E-mail: wanglanzhi@126.com
Lanzhi Wang*
College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P.R. China *Corresponding author: E-mail: wanglanzhi@126.com

Asian Journal of Chemistry, Vol. 27 No. 2 (2015): Vol 27 Issue 2

Abstract

A series of substituted ethyl 4-oxo-4-phenylbut-2-enoates were prepared and reacted with substituted o-phenylenediamine, undergone Michael addition reactions and cyclodehydration to provide novel 4-phenyl-2,3-dihydro-1,5-benzodiazepine-2- carboxylate derivatives with excellent yields. The synthetic protocol fulfilled many green-chemical requirements by using simple catalyst p-toluenesulfonic acid as activator and ethanol as solvent at room temperature.

Keywords

Michael addition 1 5-Benzodiazepine derivatives p-Toluenesulfonic acid.
Wang, S., Hu, L., Cheng, S., & Wang*, L. (2015). Synthesis of 1,5-Benzodiazepine Derivatives Using p-Toluenesulfonic Acid as Catalyst. Asian Journal of Chemistry, 27(2), 419–424. https://doi.org/10.14233/ajchem.2015.16927
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