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Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Copyright (c) 2025 Dr Manjuraj T, Prashanth Kumar P N, Vasantha Kumar B C , Mohammed Imadadulla, Shiva H. P. Rudrappa , Saleem M. Desai, Lokesh M R

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Structure of Novel Ruthenium(II) Mixed Ligands Complexes: Density Functional Theory, DNA Binding and Antimicrobial Studies via PACT Therapy

https://doi.org/10.14233/ajchem.2025.34233
T. Manjuraj
Department of Chemistry, D.R.M. Science College, Davangere-577004, India
https://orcid.org/0000-0002-2282-9739
P.N. Prashanth Kumar
Department of Chemistry, D.R.M. Science College, Davangere-577004, India
https://orcid.org/0000-0001-8582-935X
B.C. Vasantha Kumar
Department of Chemistry, D.R.M. Science College, Davangere-577004, India
https://orcid.org/0000-0001-9819-7304
Mohammed Imadadulla
Department of Chemistry, D.R.M. Science College, Davangere-577004, India
https://orcid.org/0000-0001-8618-4119
H.P. Shivarudrappa
Department of Chemistry, G.M. University, Davangere-577006, India
https://orcid.org/0000-0001-7851-7796
Saleem M. Desai
Department of Chemistry, Anjuman Art’s, Science & Commerce College, Vijayapur-586101, India
https://orcid.org/0000-0002-5560-1394
M.R. Lokesh
Department of Chemistry, H.K.B.K. College of Engineering, Bangalore-560045, India
https://orcid.org/0009-0000-4019-8689

Corresponding Author(s) : P.N. Prashanth Kumar

p.n.prashanthkumar@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Abstract

Ruthenium(II)-based complexes exhibited efficient light-harvesting capabilities that facilitate the enhanced generation of hydroxyl radicals, thereby significantly promoting antibacterial activity. The novel Ru(II) complexes can be represented as [Ru(II)(bfq)(bipy)]Cl2 (Ru-L1), [Ru(II)(bpdc)(bipy)2]Cl2 (Ru-L2) and [Ru(II)(bfq)(NCS)2]Cl2 (Ru-L3), where bfq = benzofuranquinoline carboxylic acid and bipy = bipyridine. The synthesized Ru(II) complexes were characterized with 1H NMR, IR and UV-visible techniques. The physical measurements such as viscosity measurements and denaturation thermal studies explore the behaviour of DNA binding of the synthesized Ru(II) complexes. In this context, the studies on DFT, molecular electrostatic potential and antimicrobial photodynamic therapy against Escherichia coli cells were also conducted. The obtained results show significant inhibition growth of bacterial cells was determined via PACT therapy.

Keywords

Ru(II) complexes DNA binding studies Viscosity measurements Denaturation thermal studies DFT PACT studies
(1)
Manjuraj, T.; Kumar, P. P.; Kumar, B. V.; Imadadulla, M.; Shivarudrappa, H.; Desai, S. M.; Lokesh, M. Synthesis and Structure of Novel Ruthenium(II) Mixed Ligands Complexes: Density Functional Theory, DNA Binding and Antimicrobial Studies via PACT Therapy. ajc 2025, 37, 2265-2273.
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