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Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Copyright (c) 2025 CHANDRASEKARAN N, Dr.D. Madheswari, Dr.S.Sudarsan

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Spectral and Biofunctional Evaluation of Aniline-o-Toluidine Nanostructured Copolymer: Assessing the Cytotoxicity Activity on MG-63 Cancer Cell Lines

https://doi.org/10.14233/ajchem.2025.34166
N. Chandrasekaran
Department of Chemistry, Sri Vidya Mandir Arts and Science College (Autonomous), Katteri, Uthangarai, Krishnagiri-636902, India; Department of Chemistry, Periyar University, Salem-636011, India
https://orcid.org/0000-0002-8580-626X
D. Madheswari
Department of Chemistry, Government Arts College for Women, Salem-636008, India
https://orcid.org/0000-0003-0498-5356
S. Sudarsan
Department of Chemistry, Saveetha Engineering College, Thandalam, Chennai-602105, India
https://orcid.org/0000-0002-6655-3519

Corresponding Author(s) : D. Madheswari

drmadhu6666@yahoo.com

Asian Journal of Chemistry, Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Abstract

In this work, poly(aniline-co-o-toluidine) (POT) nanostructured porous copolymer was synthesized through chemical polymerization in the presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The obtained POT copolymers were investigated by FT-IR, XRD, UV and SEM-EDX techniques. The distinct antibacterial and antifungal activities have exhibited by the as-synthesized copolymer. Various bacterial strains such as Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae have possess better antimicrobial efficacy than polyaniline. Furthermore, the antifungal properties of POT have exhibited greater effectiveness than those of polyaniline against Candida albicans and Aspergillus niger strains. The antioxidant capacity has measured against DPPH radicals highlighted a stronger activity in POT copolymer, with IC50 values of 29.4 µg/mL for polyaniline and 41.02 µg/mL for POT copolymer. Additionally, the cytotoxicity has been performed on MG-63 cancer cell lines, which indicated an IC50 value of 58.95 µg/mL for POT copolymer. The obtained results revealed that the development of POT based copolymer that are promising candidates for various applications, including biomedical, genetic engineering, pharmaceutical, and drug delivery fields. The obtained POT copolymer exhibited as an excellent antibacterial and anticancer activity, suggesting its potential roles in tissue engineering scaffolds, anticancer treatments, and various biomedical applications.

Keywords

Copolymer Aniline Surfactant o-Toluidine Cancer cell lines Microbial activities
(1)
Chandrasekaran, N.; Madheswari, D.; Sudarsan, S. Spectral and Biofunctional Evaluation of Aniline-O-Toluidine Nanostructured Copolymer: Assessing the Cytotoxicity Activity on MG-63 Cancer Cell Lines. ajc 2025, 37, 2274-2280.
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