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Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

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Spectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)-1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes

https://doi.org/10.14233/ajchem.2021.23214
Manish Kumar
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India
Poonam Jangra Darolia
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India
Nidhi Antil
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India
Mahak Dalal
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India
Jitender Narwal
Department of Chemistry, Janta Vidya Mandir Ganpat Rai Rasiwasia College, Charkhi Dadri-127306, India
K.K. Verma
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India
Sapana Garg
Department of Chemistry, Maharishi Dayanand University, Rohtak-124001, India

Corresponding Author(s) : Sapana Garg

sapanagarg1511@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

Abstract

Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dione and 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type (RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and 3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV) complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass, 1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometry have been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find the binding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus (3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened against bacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligand towards different studied microorganisms.

Keywords

Organotellurium(IV) complexes p-Aminothiophenol Antimicrobial activity 1-Phenylindoline-2,3-dione
Kumar, M., Jangra Darolia, P., Antil, N., Dalal, M., Narwal, J., Verma, K., & Garg, S. (2021). Spectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)-1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes. Asian Journal of Chemistry, 33(8), 1749–1756. https://doi.org/10.14233/ajchem.2021.23214
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