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Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

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Synthesis and Cytotoxic Studies of Pyrrolopyrimidine Derivatives

https://doi.org/10.14233/ajchem.2021.23261
Rangaswamy Roopashree
Department of Chemistry, Jain Deemed to be University, Bengaluru-560069, India
Toreshettahally R. Swaroop
DOS in Organic Chemistry, University of Mysore, Mysuru-570006, India
Chalya M. Shivaprasad
Department of Chemistry, Government First Grade College for Women, Vijayanagara, Mysuru-570032, India
Swamy Jagadish
DOS in Chemistry, University of Mysore, Mysuru-570006, India
Kanchugarakoppal S. Rangappa
Institution of Excellence, University of Mysore, Mysuru-570006, India

Corresponding Author(s) : Toreshettahally R. Swaroop

swarooptr@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

Abstract

The synthesis and in vitro cytotoxicity of new pyrrolopyrimidine derivatives is reported in this work. All the compounds were characterized by IR, NMR and MS. They are examined for cytotoxic activity against HeLa. Pyrrolopyrimidine derivatives of benzyl amine (8g) and 4-bromoaniline (8k) showed a potent activity, which is comparable to that of standard Sorafenib.

Keywords

Cytotoxic Pyrrolopyridines in vitro HeLa
Roopashree, R., R. Swaroop, T., M. Shivaprasad, C., Jagadish, S., & S. Rangappa, K. (2021). Synthesis and Cytotoxic Studies of Pyrrolopyrimidine Derivatives. Asian Journal of Chemistry, 33(8), 1855–1860. https://doi.org/10.14233/ajchem.2021.23261
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