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Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

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Synthesis, Characterization and Biological Evaluation of Metal(II) Complexes Containing Triphenylphosphine and Schiff Base Ligand Based on 3-Methoxysalicylaldehyde

https://doi.org/10.14233/ajchem.2021.23262
G. Gokulnath
Department of Chemistry, Government Arts College (Autonomous), Salem-636007, India
P. Anitha
Department of Chemistry, Government College of Engineering, Salem-636011, India
R. Manikandan
Department of Chemistry, Loyola College of Arts and Science, Rasipuram, Namakkal-636202, India
C. Umarani
Department of Chemistry, Government Arts College (Autonomous), Salem-636007, India

Corresponding Author(s) : C. Umarani

cuchem1966@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

Abstract

Schiff base ligand (HL) derived from condensation of 3-methoxy salicylaldehyde with 4-aminobenzoic acid and its metal(II) complexes containing triphenylphosphine of the type [MCl(PPh3)(L)] (M = Ni2+, Co2+ or Cu2+; L = bitendate Schiff base ligand) have been synthesized. All the metal(II) complexes were characterized by analytical and spectroscopic (FT-IR, electronic, ESI-Mass, ESR, 1H, 13C NMR and 31P NMR) techniques. All the synthesized compounds were evaluated for in vitro antimicrobial efficiency against Gram-positive bacteria, Gram-negative bacteria and fungai using the agar well diffusion method. Anticancer activity in vitro of the ligand and its metal(II) complexes were also screened against MCF-7 cancer cell lines (human breast cancer cell line).

Keywords

Schiff base Metal(II) complexes 3-Methoxy salicylaldehyde 4-Aminobenzoic acid Biological activity
Gokulnath, G., Anitha, P., Manikandan, R., & Umarani, C. (2021). Synthesis, Characterization and Biological Evaluation of Metal(II) Complexes Containing Triphenylphosphine and Schiff Base Ligand Based on 3-Methoxysalicylaldehyde. Asian Journal of Chemistry, 33(8), 1819–1823. https://doi.org/10.14233/ajchem.2021.23262
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