Issue

Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Copyright (c) 2021 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Variation in Anti-Glycation and Cross-Link Breaking Effects of Crude Extracts of Moringa oleifera Leaf, Seed and Root

https://doi.org/10.14233/ajchem.2021.23058
O.I. Adeniran
Department of Biochemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
D.B. Msomi
Department of Biochemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
M.T. Olivier
Department of Chemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
M.A. Mogale
Department of Biochemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa

Corresponding Author(s) : O.I. Adeniran

seyefunmiadeniran@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

Study and comparing the anti-glycation and cross-link breaking effects of Moringa oleifera leaf, seed and root extracts with aminoguanidine, a known inhibitor of advanced glycation end-products (AGEs). Their phytochemical composition and extraction yields were also assessed. All seed and root extracts demonstrated significantly higher anti-glycation effect than aminoguanidine against total immunogenic AGEs (p < 0.05). Both seed and root polar (methanol and water) extracts exhibited significantly higher anti-glycation effect against N′-(carboxymethyl)lysine than aminoguanidine (p < 0.05). Polar extracts of all M. oleifera tested parts demonstrated higher anti-glycation activity against fluorescent AGEs than aminoguanidine (p < 0.05). With exception to the aqueous root extracts, all leaf, seed and root extracts of M. oleifera demonstrated an ability to break AGE-protein cross-links. The highest cross-link breaking effect was exhibited by ethyl acetate extract of leaves.The methanol extract of seeds of M. oleifera showed the presence of all tested secondary metabolites.

Keywords

Moringa oleifera Anti-glycation Cross-link Crude extracts
Adeniran, O., Msomi, D., Olivier, M., & Mogale, M. (2021). Variation in Anti-Glycation and Cross-Link Breaking Effects of Crude Extracts of Moringa oleifera Leaf, Seed and Root. Asian Journal of Chemistry, 33(5), 1137–1143. https://doi.org/10.14233/ajchem.2021.23058
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. M.N. Lund and C.A. Ray, J. Agric. Food Chem., 65, 4537 (2017); https://doi.org/10.1021/acs.jafc.7b00882
  2. M. Navarro and F.J. Morales, Food Res. Int., 92, 56 (2017); https://doi.org/10.1016/j.foodres.2016.12.017
  3. A.A. Chinchansure, A. Korwar, A.M. Kulkarni and S.P. Joshi, RSC Adv., 5, 31113 (2015); https://doi.org/10.1039/C4RA14211J
  4. S. Khangholi, F.A.A. Majid, N.J.A. Berwary, F. Ahmad and R.B.A. Aziz, Planta Med., 82, 32 (2016); https://doi.org/10.1055/s-0035-1558086
  5. T. Suantawee, K. Wesarachanon, K. Anantsuphasak, T. Daenphetploy, S. Thien-Ngern, T. Thilavech, P. Pasukamonset, S. Ngamukote and S. Adisakwattana, J. Food Sci. Technol., 52, 3843 (2015); https://doi.org/10.1007/s13197-014-1452-1
  6. H.K.I. Perera and H.A.S.K. Ranasinghe, Asian J. Med. Sci., 6, 28 (2014); https://doi.org/10.3126/ajms.v6i1.10181
  7. J. Lin, C. Wu and G. Yen, J. Agric. Food Chem., 66, 2065 (2018); https://doi.org/10.1021/acs.jafc.7b05943
  8. P. Deetae, P. Parichanon, P. Trakunleewatthana, C. Chanseetis and S. Lertsiri, Food Chem., 133, 953 (2012); https://doi.org/10.1016/j.foodchem.2012.02.012
  9. I. Grzegorczyk-Karolak, K. Golab, J. Gburek, H. Wysokiñska and A. Matkowski, Molecules, 21, 739 (2016); https://doi.org/10.3390/molecules21060739.;
  10. Z. Hegab, S. Gibbons, L. Neyses and M.A. Mamas, World J. Cardiol., 4, 90 (2012); https://doi.org/10.4330/wjc.v4.i4.90
  11. R. Nagai, D.B. Murray, T.O. Metz and J.W. Baynes, Persp. Diabetes, 61, 549 (2012); https://doi.org/10.2337/db11-1120
  12. M. Saraswat, P.Y. Reddy, P. Muthenna and G.B. Reddy, Br. J. Nutr., 101, 1714 (2009); https://doi.org/10.1017/S0007114508116270
  13. V.M. Monnier, W. Sun, D.R. Sell, X. Fan, I. Nemet and S. Genuth, Clin. Chem. Lab. Med., 52, 21 (2014); https://doi.org/10.1515/cclm-2013-0174
  14. A. Elosta, T. Ghous and N. Ahmed, Curr. Diabetes Res., 8, 92 (2012); https://doi.org/10.2174/157339912799424528
  15. C. Kim, K. Jo, J.S. Kim, M. Pyo and J. Kim, BMC Complement. Altern. Med., 17, 430 (2017); https://doi.org/10.1186/s12906-017-1925-7
  16. M.A. Mogale, S.L. Lebelo, N. Thovhogi, A.N. de Freitas and L.J. Shai, Afr. J. Biotechnol., 10, 15033 (2011); https://doi.org/10.5897/AJB11.1408
  17. S. Ho and P. Chang, Sci. Res., 3, 995 (2012).
  18. G. Munch, R. Keis, A. Weßels, P. Riederer, U. Bahner, A. Heidland, T. Niwa, H. Lemke and R. Schinzel, Eur. J. Clin. Chem. Clin. Biochem.,35, 669 (1997); https://doi.org/10.1515/cclm.1997.35.9.669
  19. G. Cheng, L.-L. Wang, L. Long, H.-Y. Liu, H. Cui, W.-S. Qu and S. Li, Br. J. Pharmacol., 152, 1196 (2007); https://doi.org/10.1038/sj.bjp.0707533
  20. S.H. Ganatra, P.D. Shweta and S.U. Patil, J. Chem. Pharm. Res., 4, 2380 (2012).
  21. B.S. Joseph, P.H. Kumbhare and M.C. Kale, Int. Res. J. Sci. Eng., 1, 55 (2013).
  22. A. Soni and S. Sosa, J. Pharmacogn. Phytochem., 2, 22 (2013).
  23. T. Bansode, and B.K. Salalkar, Int. J. Pharma. Bio. Sci., 6, 550 (2015).
  24. M.S. Ahmad and N. Ahmed, J. Nutr., 136, 796S (2006); https://doi.org/10.1093/jn/136.3.796S
  25. P. Chumark, P. Khunawat, Y. Sanvarinda, S. Phornchirasilp, N.P. Morales, L. Phivthong-ngam, P. Ratanachamnong, S. Srisawat and K.S. Pongrapeeporn, J. Ethnopharmacol., 116, 439 (2008); https://doi.org/10.1016/j.jep.2007.12.010
  26. S.C. Mahajan and A.A. Mehta, J. Ethnopharmacol., 130, 183 (2010); https://doi.org/10.1016/j.jep.2010.04.024
  27. R. Gupta, M. Mathur, V.K. Bajaj, P. Katariya, S. Yadav, R. Kamal and R.S. Gupta, J. Diabetes, 4, 164 (2012); https://doi.org/10.1111/j.1753-0407.2011.00173.x
  28. P. Nunthanawanich, W. Sompong, S. Sirikwanpong, K. Mäkynen, S. Adisakwattana, W. Dahlan and S. Ngamukote, Springerplus, 5, 1098 (2016); https://doi.org/10.1186/s40064-016-2759-3
  29. W. Sangkitikomol, A. Rocejanasaroj and T. Tencomnao, Genet. Mol. Res., 13, 723 (2014); https://doi.org/10.4238/2014.January.29.3
  30. O.I. Adeniran and M.A. Mogale. Acta Horticulturae ISHS Proc. II International Symposium on Moringa (2020) (In press).
  31. A.J. Akinyeye, E.O. Solanke and I.O. AdebiyI, Int. J. Res. Medical Health Sci., 4, 1 (2014).
  32. B. Ncube, J.F. Finnie and J. Van Staden, S. Afr. J. Bot., 77, 387 (2011); https://doi.org/10.1016/j.sajb.2010.10.004
  33. L. Nchabeleng, F.N. Mudau and I.K. Mariga, J. Med. Plants Res., 6, 1662 (2012); https://doi.org/10.5897/JMPR11.1453
  34. T. Tshabalala, A.R. Ndhlala, B. Ncube, H.A. Abdelgadir and J. van Staden, S. Afr. J. Bot., 129, 106 (2020); https://doi.org/10.1016/j.sajb.2019.01.029
  35. T. Shoko, V.J. Maharaj, D. Naidoo, M. Tselanyane, R. Nthambeleni, E. Khorombi and Z. Apostolides, BMC Complement. Altern. Med., 18, 54 (2018); https://doi.org/10.1186/s12906-018-2112-1
  36. J. Chompoo, A. Upadhyay, W. Kishimoto, T. Makise and S. Tawata, Food Chem., 129, 709 (2011); https://doi.org/10.1016/j.foodchem.2011.04.034
  37. L. Ferchichi, S. Derbre, K. Mahmood, K. Toure, D. Guilet, M. Litaudon, K. Awang, A.H. Hadi, A.M. Le Ray and P. Richomme, Phytochemistry, 78, 98 (2012); https://doi.org/10.1016/j.phytochem.2012.02.006
  38. H. Younus and S. Anwar, Int. J. Health Sci. Qassim Univ., 10, 262 (2016).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 3 Download : 0