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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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A Green Synthesis of 1,5-Benzodiazepines using Reusable-Heterogeneous Silica Sulfuric Acid Catalyst under Solvent-Free Conditions and their Antileukemic Activity

https://doi.org/10.14233/ajchem.2021.23103
Kachigere B. Harsha
Centre for Materials Science and Technology, Vijnana Bhavan, University of Mysore, Mysuru-570006, India
agirikoppal V. Kavitha
Government College for Women (Autonomous), University of Mysore, Mandya-571401, India
Toreshettahally R. Swaroop
Department of Studies in Organic Chemistry, University of Mysore, Mysuru-570006, India
Shobith Rangappa
Adichunchangiri Institute for Molecular Medicine, Nagamangala-571448, India
Kanchugarakoppal S. Rangappa
Institution of Excellence, University of Mysore, Mysuru-570006, India

Corresponding Author(s) : Toreshettahally R. Swaroop

swarooptr@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

1,5-Benzodiazepine derivatives are readily assembled from o-phenylene diamine and ketones containg α-hydrogen atoms by means of simple cyclocondensation via sp3 C-H activation promoted by an efficient heterogeneous silica sulfuric acid catalyst. Eco-friendliness, good yields, easy workup, reusable catalyst, short reaction times, high atom economy and solvent-free conditions are the noteworthy features of this protocol. These benzodiazepines are chosen for the evaluation of antiproliferative activity against different leukemia cell lines. Among the investigated compounds, 3g is the best antiproliferative agent against all the cell lines tested. Also, current preliminary analysis showed that compound 3g phosphorylates ERK1/2 and induces G1 arrest in K562 cells.

Keywords

Benzodiazepines Heterogeneous Solvent-free Anticancer Leukemia.
B. Harsha, K., V. Kavitha, agirikoppal, R. Swaroop, T., Rangappa, S., & S. Rangappa, K. (2021). A Green Synthesis of 1,5-Benzodiazepines using Reusable-Heterogeneous Silica Sulfuric Acid Catalyst under Solvent-Free Conditions and their Antileukemic Activity. Asian Journal of Chemistry, 33(5), 1006–1012. https://doi.org/10.14233/ajchem.2021.23103
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