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Vol. 33 No. 4 (2021): Vol 33 Issue 4

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Anti-inflammatory and Antioxidant Activities of Teucrium polium Leaf Extract and its Phenolic and Flavonoids Content

https://doi.org/10.14233/ajchem.2021.23096
Khaled Qabaha
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Arab American University, Jenin, Palestine
Thameen Hijawi
Department of Development Studies, Faculty of Arts, Al-Quds University, P.O. Box 20002, East Jerusalem, Palestine
Abdallah Mahamid
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Arab American University, Jenin, Palestine
Haneen Mansour
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Arab American University, Jenin, Palestine
Ahmad Naeem
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Arab American University, Jenin, Palestine
Jehad Abbadi
Department of Biology, Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, East Jerusalem, Palestine
Fuad Al-Rimawi
Department of Chemistry, Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, East Jerusalem, Palestine

Corresponding Author(s) : Fuad Al-Rimawi

falrimawi@staff.alquds.edu

Asian Journal of Chemistry, Vol. 33 No. 4 (2021): Vol 33 Issue 4

Abstract

Teucrium polium leaf is one of the folkloric medicinal plants used traditionally to treat many diseases in the Palestinian community. It has antibacterial antioxidant and anti-inflammatory consequences. Present study aims the evaluating the in vitro inhibitory effect of Teucrium polium leaf extracts on tumor necrosis factor-α (TNF-α) using polymorphonuclear cells (PMNCs), in addition to determine its antioxidant and total phenolic and flavonoids contents. Polymorphonuclear cells were withdrawn from whole blood according to Histopaque (Ficol-1077) method. Blood cells were cultured in an enriched Roswell Park Memorial Institute (RBMI) medium. The levels of tumor necrosis factor (TNF-α) were determined after 24 h using LPS stimulation. Total phenolic contents, flavonoids contents and antioxidant activity were measured using spectrophotometric method. The TNF-α concentrations were compared using paired-samples t test. The leaf extracts of Teucrium polium revealed significant reduction in terms of TNF-α levels. The extract contained high phenolic and flavonoids contents and its antioxidant activities were remarkable. The reduced values in the TNF-α levels as affected by Teucrium polium leaf extracts indicate its effect in anti-inflammation. The plant is rich with polyphenolic compounds and flavonoids and has strong antioxidant activity. The observed anti-inflammatory effect of the extracts under study may be discussed as the influence of the significant presence of the phenolic compounds and flavonoids.

Keywords

Teucrium polium Plant extracts Anti-inflammatory effect TNF-α
Qabaha, K., Hijawi, T., Mahamid, A., Mansour, H., Naeem, A., Abbadi, J., & Al-Rimawi, F. (2021). Anti-inflammatory and Antioxidant Activities of Teucrium polium Leaf Extract and its Phenolic and Flavonoids Content. Asian Journal of Chemistry, 33(4), 881–884. https://doi.org/10.14233/ajchem.2021.23096
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References
  1. S. Niazmand, N.A. Zabihi, S.M. Mousavi, M. Mahmoudabady, M. Soukhtanloo and F. Sohrabi, Int. J. Prev. Med., 9, 110 (2018); https://doi.org/10.4103/ijpvm.IJPVM_189_17
  2. F. Sharififar, G. Dehghn-Nudeh and M. Mirtajaldini, Food Chem., 112, 885 (2009); https://doi.org/10.1016/j.foodchem.2008.06.064
  3. S.M.M. Shah and S.M.H. Shah, BMC Complement. Altern. Med., 15, 351 (2015); https://doi.org/10.1186/s12906-015-0872-4
  4. S. Bahramikia and R. Yazdanparast, Phytother. Res., 26, 1581 (2012); https://doi.org/10.1002/ptr.4617
  5. L. Nie, Y. Oishi, I. Doi, H. Shibata and I. Kojima, Cell Calcium, 22, 75 (1997); https://doi.org/10.1016/S0143-4160(97)90107-X
  6. H. Eskandary, S. Rajabalian, T. Yazdi, M. Eskandari, K. Fatehi and N.A. Ganjooei, Int. J. Pharmacol., 3, 435 (2007); https://doi.org/10.3923/ijp.2007.435.437
  7. F. Sheikhbahaei, M. Khazaei and S.N. Nematollahi-Mahani, Adv. Pharm. Bull., 8, 131 (2018); https://doi.org/10.15171/apb.2018.016
  8. W.H. Mohammed, Eng. Technol. J., 28, 6149 (2010).
  9. R.M. Al-Ashban, D.A. Barrett and A.H. Shah, J. Herbs Spices Med. Plants, 11, 27 (2006); https://doi.org/10.1300/J044v11n04_04
  10. E. Darabpour, H. Motamedi and S.M.S. Nejad, Asian Pac. J. Trop. Med., 3, 124 (2010); https://doi.org/10.1016/S1995-7645(10)60050-8
  11. E. Sevindik, Z.T. Abacý, C. Yamaner and M. Ayvaz, Biotechnol. Biotechnol. Equip., 30, 375 (2016); https://doi.org/10.1080/13102818.2015.1131626
  12. K.I. Qabaha, Qabaha Afr. J. Tradit. Complement Alter.n Med., 10, 101 (2013); https://doi.org/10.4314/ajtcam.v10i4.17
  13. J.D. Gbenou, J.F. Ahounou, H.B. Akakpo, A. Laleye, E. Yayi, F.Gbaguidi, L. Baba-Moussa, R. Darboux, P. Dansou, M. Moudachirou and S.O. Kotchoni, Mol. Biol. Rep., 40, 1127 (2013); https://doi.org/10.1007/s11033-012-2155-1
  14. M. Gaestel, A. Kotlyarov and M. Kracht, Nat. Rev. Drug Discov., 8, 480 (2009); https://doi.org/10.1038/nrd2829
  15. C. Nathan, Nature, 420, 846 (2002); https://doi.org/10.1038/nature01320
  16. M. Mihara, I. Miyai, N. Hattori, M. Hatakenaka, H. Yagura, T. Kawano, M. Okibayashi, N. Danjo, A. Ishikawa, Y. Inoue and K. Kubota, PLoS One, 7, e32234 (2012); https://doi.org/10.1371/journal.pone.0032234
  17. Y. Oe, K. Mochizuki, R. Miyauchi, Y. Misaki, N. Kasezawa, K. Tohyama and T. Goda, J. Nutr. Sci. Vitaminol., 61, 263 (2015); https://doi.org/10.3177/jnsv.61.263
  18. J.Y. Cho, P.S. Kim, J. Park, E.S. Yoo, K.U. Baik, Y.-K. Kim and M.H. Park, J. Ethnopharmacol., 70, 127 (2000); https://doi.org/10.1016/S0378-8741(99)00154-3
  19. K. Qabaha, F. Al-Rimawi, A. Qasem and S.A. Naser, J. Med. Food, 21, 302 (2018); https://doi.org/10.1089/jmf.2017.0070
  20. H. Kallassy, M. Fayyad-Kazan, R. Makki, Y. EL-Makhour, H. Rammal, D.Y. Leger, V. Sol, H. Fayyad-Kazan, B. Liagre and B. Badran, Med. Sci. Monit. Basic Res., 23, 313 (2017); https://doi.org/10.12659/MSMBR.905056
  21. R.H. Liu, J. Nutr., 134, 3479S (2004); https://doi.org/10.1093/jn/134.12.3479S
  22. W. Ning, X. Peng, L. Ma, L. Cui, X. Lu, J. Wang, J. Tian, X. Li, W. Wang and L. Zhang, Innov. Food Sci. Emerg. Technol., 13, 231 (2012); https://doi.org/10.1016/j.ifset.2011.10.005
  23. Z. Ahmadi, M. Sattari, B. Tabarraee and M. Bigdeli, J. Arak Univ. Med. Sci., 14, 1 (2011).
  24. F. Rahmouni, L. Hamdaoui and T. Rebai, Arch. Physiol. Biochem.,123, 313 (2017); https://doi.org/10.1080/13813455.2017.1333517
  25. M. Amraei, A. Ghorbani, Y. Seifinejad, S.F. Mousavi, M. Mohamadpour and E. Shirzadpour, J. Inflamm. Res., 11, 265 (2018); https://doi.org/10.2147/JIR.S165172
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