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Vol. 33 No. 4 (2021): Vol 33 Issue 4

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Isolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei: Their Anti-lung Cancer Cell and in vivo Anti-aging Activity

https://doi.org/10.14233/ajchem.2021.23051
Preeyanuch Manohong
Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand
Nilubon Sornkaew
Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand
Krai Meemon
Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
Kawita Chumphoochai
Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
Prasert Sobhon
Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
Montakan Tamtin
Department of Fisheries, Coastal Aquatic Feed Research Institute, Coastal Fisheries Research and Development Bureau, Petchaburi, Thailand
Jirapast Sichaem
Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand
Withawat Mingvanish
Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
Choladda Srisuwannaket
Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
Withawat Mingvanish
Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand
Nakorn Niamnont
Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand

Corresponding Author(s) : Nakorn Niamnont

nakorn.nia@kmutt.ac.th

Asian Journal of Chemistry, Vol. 33 No. 4 (2021): Vol 33 Issue 4

Abstract

This study aimed to evaluate the bioactivity and phytochemical investigation in red algae Halymenia durvillei. The polarity based solvent partition (hexane, ethyl acetate, butanol and water) of H. durvillei ethanolic crude were used for characterization. The present results of the ethyl acetate extract of red alga H. durvillei generated a 3-(hydroxyacetyl)indole (1), indole-3-carboxylic acid (2) as well as two fatty acids viz. palmitic acid (3) and α-linoleic acid (4). The viability against lung cancer cells of compounds 1 and 2 showed moderate activities against the A549 cell line with inhibition percentages of 12.97% and 25.81%, respectively. Analysis of the dose response of C. elegans anti-aging assay indicated that the survival rate of compound 1 was 12.62% while it was 11.04% for compound 2. Furthermore, H. durvillei isolation was used as an antioxidant, anti-cancer cell and anti-aging resource.

Keywords

3-(Hydroxyacetyl)indole Halymenia durvillei Anti-aging activity Anti-cancer cell
Manohong, P., Sornkaew, N., Meemon, K., Chumphoochai, K., Sobhon, P., Tamtin, M., … Niamnont, N. (2021). Isolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei: Their Anti-lung Cancer Cell and in vivo Anti-aging Activity. Asian Journal of Chemistry, 33(4), 775–780. https://doi.org/10.14233/ajchem.2021.23051
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