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Vol. 33 No. 3 (2021): Vol 33 Issue 3

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Natural Phytochemicals and Biological Activities of Wild Grape (Ampelocissus martinii Planch.) Root Extract

https://doi.org/10.14233/ajchem.2021.23063
P. Siripipatthana
Protein and Enzyme Technology Research Unit, Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand
P. Srihanam
Creative and Innovation Chemistry Research Unit and Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand
A. Sangdee
Microbiology and Applied Microbiology Research Unit, Department of Biology, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand

Corresponding Author(s) : P. Siripipatthana

patthraporn.s@msu.ac.th; nanasara1@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 3 (2021): Vol 33 Issue 3

Abstract

A hydromethanolic root extract of Ampelocissus martinii Planch. (A. martinii) was analyzed by standard methods for its phytochemical content, antioxidant activity, α-amylase and α-glucosidase inhibitions and antibacterial activities. The root extract exhibited the highest content of saponins, followed by phenols, proanthocyanidin and flavonoids, respectively. It showed high antioxidant activity in FRAP and CUPRAC assays. The root extract and standard Trolox had similar antioxidant activities in the DPPH and ABTS assay. It also showed much higher α-amylase and α-glucosidase inhibitory activity compared to standard acarbose. Moreover, the root extract inhibited all tested Gram-positive bacteria with the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 6.25 mg/mL. These results indicate that A. martinii root can be pharmaceutically used as active ingredients to prevent bacterial infection and radical-related diseases especially diabetes.

Keywords

Phytochemicals Enzyme inhibition Antioxidant Ampelocissus martinii
Siripipatthana, P., Srihanam, P., & Sangdee, A. (2021). Natural Phytochemicals and Biological Activities of Wild Grape (Ampelocissus martinii Planch.) Root Extract. Asian Journal of Chemistry, 33(3), 545–550. https://doi.org/10.14233/ajchem.2021.23063
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