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Vol. 33 No. 3 (2021): Vol 33 Issue 3

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Antimicrobial, Structure-Activity Relationship and Computational Studies of Some Synthesized Chalcone Derivatives

https://doi.org/10.14233/ajchem.2021.23028
Md Mizanur Rahman Badal
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Md Tarikul Islam
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Reshma Parvin
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Md. Abul Khaer Morol
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Md Maniruzzaman
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Mohammad Abu Yousuf
Department of Chemistry, Khulna University of Engineering &Technology, Khulna-9203, Bangladesh
Md Ershad Halim
Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

Corresponding Author(s) : Md Mizanur Rahman Badal

mizan@chem.kuet.ac.bd

Asian Journal of Chemistry, Vol. 33 No. 3 (2021): Vol 33 Issue 3

Abstract

Several chalcones viz. 1,3-diaryl-2-propane-1-one (1a), 3-(4-hydroxy phenyl)-1-phenyl-2-propane-1-one (1b), 3-(4-amino-phenyl)-1-phenyl-2-propane-1-one (1c) and their derivatives 2-ethoxy-4,6-diphenyl-4H-pyran-3-carboxylic acid ethyl ester (2a), 4-(4-hydroxy-phenyl)-7,7-dimethyl-2-phenyl-4,6,7,8-tetrahydro-chromen-5-one (2b) and 7-(4-amino-phenyl)-5-phenyl-1,5-dihydropyrano[2,3-d]pyrimidine-2,4-dione (2c) have been synthesized following both conventional and microwave irradiation methods. The structures of the isolated compounds were elucidated on the basis of UV-visible, FTIR, 1H NMR spectral data. The antimicrobial results showed some remarkable facts about the structure–activity relationship, which states that the electronic atmosphere around the chalcone derivative moieties and substituents considerably affect the antimicrobial potential of the synthesized compounds. Theoretical calculation as well as antimicrobial activity of the compounds were also studied.

Keywords

Chalcone Antimicrobial activity Density functional theory Microwave irradiation
Mizanur Rahman Badal, M., Tarikul Islam, M., Parvin, R., Abul Khaer Morol, M., Maniruzzaman, M., Abu Yousuf, M., & Ershad Halim, M. (2021). Antimicrobial, Structure-Activity Relationship and Computational Studies of Some Synthesized Chalcone Derivatives. Asian Journal of Chemistry, 33(3), 644–650. https://doi.org/10.14233/ajchem.2021.23028
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