Design, Synthesis and Antibacterial Activity of N-(3-((4-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide Derivatives

B. Siva Reddy; K.R.S. Prasad

doi:10.14233/ajchem.2021.23039

Issue

Vol. 33 No. 3 (2021): Vol 33 Issue 3

Issue Published : February 16, 2021

This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Synthesis and Antibacterial Activity of N-(3-((4-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide Derivatives

https://doi.org/10.14233/ajchem.2021.23039

B. Siva Reddy

Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur-522502, India

K.R.S. Prasad

Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur-522502, India

Corresponding Author(s) : B. Siva Reddy

bassi.sivareddy@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 3 (2021): Vol 33 Issue 3
Article Published : February 16, 2021

Abstract

A new series of N-(3-((4-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide derivatives (10a-h)were synthesized by the reaction of 3-((4-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-amine (8) with various carboxylic acids in the presence of T₃P catalyst. The reaction is usually furnished within 60 min with good isolated yields. Coupling of 6-(2,2,2-trifluoroethoxy) nicotinic acid (1) with Weinreb amine hydrochloride gave N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy) nicotinamide (2). Compound 3 was synthesized by the Grignard reaction of compound 2 with methylmagnesium bromide. Bromination of compound 3 with N-bromo succinamide to obtain 2-bromo-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethan-1-one (4), which was reacted with 2-(3-(((benzyloxy)carbonyl)amino)oxetan-3-yl)acetic acid (5) gave 2-oxo-2-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl 2-(3-(((benzyloxy)carbonyl)amino)oxetan-3-yl)acetate (6). Compound 7 was synthesized by the cyclization of compound 6 with ammonium acetate. Finally, debenzylation of compound 7 gave 3-((4-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-amine (8). All the synthesized amide compounds were characterized by analytical spectral techniques, like ¹H & ¹³C NMR and LCMS and also evaluated their antibacterial activity.

Keywords

Pyridine-imidazole derivatives Imidazole amide derivatives Antibacterial activity.

Siva Reddy, B., & Prasad, K. (2021). Design, Synthesis and Antibacterial Activity of N-(3-((4-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide Derivatives. Asian Journal of Chemistry, 33(3), 577–582. https://doi.org/10.14233/ajchem.2021.23039

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Issue

Vol. 33 No. 3 (2021): Vol 33 Issue 3

Design, Synthesis and Antibacterial Activity of N-(3-((4-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)-1H-imidazol-2-yl)methyl)oxetan-3-yl)amide Derivatives

Corresponding Author(s) : B. Siva Reddy

Abstract

Keywords

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