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Mechanochemistry in Action: Exploitation of Internal Acid Catalysis in Solvent-Free Synthesis of Imines and Evaluation of Radical Scavenging Activities of Imino Derivatives

https://doi.org/10.14233/ajchem.2021.23009
Madhushree Das Sarma
Department of Chemistry, Acharya Prafulla Chandra College, New Barrackpore-700131, India
Subhojit Ghosh
Department of Chemistry, Acharya Prafulla Chandra College, New Barrackpore-700131, India

Corresponding Author(s) : Subhojit Ghosh

sgorganic1971@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 2 (2021): Vol 33 Issue 2

Abstract

Mechanochemical protocol has been exploited to accomplish the synthesis of imino derivatives from aromatic amines with acidic functionalities and different aromatic aldehydes in excellent to nearly quantitative yields. Presence of acidic groups in the aromatic amines has been found to have profound influence on the course of the reaction. The prepared imines were screened for in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Some of the prepared imino derivatives displayed good to moderate antioxidant property when compared with standard natural antioxidant (L-ascorbic acid).

Keywords

Mechanochemistry Internal acid catalysis Solvent-free reaction Radical scavenging activity
Das Sarma, M., & Ghosh, S. (2021). Mechanochemistry in Action: Exploitation of Internal Acid Catalysis in Solvent-Free Synthesis of Imines and Evaluation of Radical Scavenging Activities of Imino Derivatives. Asian Journal of Chemistry, 33(2), 345–349. https://doi.org/10.14233/ajchem.2021.23009
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