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A Simple and Convenient Method for Synthesis of Artemisinin Dimer through Aliphatic Nitro Compounds

https://doi.org/10.14233/ajchem.2021.22918
Nitin Srivastava
Department of Chemistry, Amity University Uttar Pradesh Lucknow Campus, Lucknow-226028, India
B.K. Rathore
Department of Chemistry, Fakhruddin Ali Ahmed Government P.G. College, Mahmudabad-261203, India
R.K. Vishnoi
Department of Chemistry, Amity University Uttar Pradesh Lucknow Campus, Lucknow-226028, India
Sangeeta Bajpai
Department of Chemistry, Amity University Uttar Pradesh Lucknow Campus, Lucknow-226028, India

Corresponding Author(s) : Nitin Srivastava

nitinsriv5@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 1 (2021): Vol 33 Issue 1

Abstract

A simple way of synthesis of artemisinin dimer using nitro aliphatic compounds is reported. Herein, few artemisinin monomers and dimers have been synthesized with the help of linker nitroalkanes using iron catalyst supported on polymer (Fe/SBA-15). The synthesized artemisinin shows good anticancer and antimalarial activities.

Keywords

Substituted aliphatic compounds Polymer (Fe/SBA-15) Artemisinin dimer Biological activities
Srivastava, N., Rathore, B., Vishnoi, R., & Bajpai, S. (2020). A Simple and Convenient Method for Synthesis of Artemisinin Dimer through Aliphatic Nitro Compounds. Asian Journal of Chemistry, 33(1), 49–52. https://doi.org/10.14233/ajchem.2021.22918
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References
  1. A.Y. Sukhorukov, Front. Chem., 8, 595246 (2020); https://doi.org/10.3389/fchem.2020.595246
  2. G. Yan and M. Yang, Org. Biomol. Chem., 11, 2554 (2013); https://doi.org/10.1039/C3OB27354G
  3. R. Ballini and M. Petrini, Arkivoc, 195 (2009);https://doi.org/10.3998/ark.5550190.0010.912
  4. N. Nishiwaki, Molecules, 25, 3680 (2020); https://doi.org/10.3390/molecules25163680
  5. R. Ballini, S. Gabrielli, A. Palmieri and M. Petrini, Curr. Org. Chem., 15, 1482 (2011); https://doi.org/10.2174/138527211795378137
  6. R. Ballini and A. Palmieri, Curr. Org. Chem., 10, 2145 (2006); https://doi.org/10.2174/138527206778742632
  7. C. Czekelius and E.M. Carreira, Angew. Chem. Int. Ed., 44, 612 (2005); https://doi.org/10.1002/anie.200461879
  8. R. Ballini and A. Palmieri, Adv. Synth. Catal., 361, 5070 (2019); https://doi.org/10.1002/adsc.201900563
  9. A. Septembre-Malaterre, M.L. Rakoto, C. Marodon, Y. Bedoui, J. Nakab, E. Simon, L. Hoarau, S. Savriama, D. Strasberg, P. Guiraud, J. Selambarom and P. Gasque, Int. J. Mol. Sci., 21, 4986 (2020); https://doi.org/10.3390/ijms21144986
  10. D. Chaturvedi, A. Goswami, P.P. Saikia, N.C. Barua and P.G. Rao, Chem. Soc. Rev., 39, 435 (2010); https://doi.org/10.1039/B816679J
  11. M. Jung, X. Li, D.A. Bustos, H.N. ElSohly, J.D. McChesney and W.K. Milhous, J. Med. Chem., 33, 1516 (1990); https://doi.org/10.1021/jm00167a036
  12. G.H. Posner, P. Ploypradith, M.H. Parker, H. O’Dowd, S.H. Woo, J. Northrop, M. Krasavin, P. Dolan, T.W. Kensler, S. Xie and T.A. Shapiro, J. Med. Chem., 42, 4275 (1999); https://doi.org/10.1021/jm990363d
  13. S. Ekthawatchai, S. Kamchonwongpaisan, P. Kongsaeree, B. Tarnchompoo, Y. Thebtaranonth and Y. Yuthavong, J. Med. Chem., 44, 4688 (2001); https://doi.org/10.1021/jm0103007
  14. D. Kalita, A.T. Khan, N.C. Barua and G. Bez, Tetrahedron, 55, 5177 (1999); https://doi.org/10.1016/S0040-4020(99)00164-7
  15. B. Kalita, N.C. Barua, M.S. Bezbarua and G. Bez, Synlett, 1411 (2001); https://doi.org/10.1055/s-2001-16776
  16. J.C. Borah, S. Gogoi, J. Boruwa, B. Kalita and N.C. Barua, Tetrahedron Lett., 45, 3689 (2004); https://doi.org/10.1016/j.tetlet.2004.02.150
  17. N. Gogoi, J. Boruwa and N.C. Barua, Tetrahedron Lett., 46, 7581 (2005); https://doi.org/10.1016/j.tetlet.2005.08.153
  18. J. Boruwa and N.C. Barua, Tetrahedron, 62, 1193 (2006); https://doi.org/10.1016/j.tet.2005.10.070
  19. N. Gogoi, J. Boruwa and N.C. Barua, Eur. J. Org. Chem., 1722 (2006); https://doi.org/10.1002/ejoc.200500833
  20. P.P. Saikia, G. Baishya, A. Goswami and N.C. Barua, Tetrahedron Lett., 49, 6508 (2008); https://doi.org/10.1016/j.tetlet.2008.08.113
  21. A. Goswami, P.P. Saikia, N.C. Barua, M.J. Bordoloi, A. Yadav, T.C. Bora, B.K. Gogoi, A.K. Saxena, N. Suri and M. Sharma, Bioorg. Med. Chem. Lett., 20, 359 (2010); https://doi.org/10.1016/j.bmcl.2009.10.097
  22. R. Ballini, L. Barboni and G. Giarlo, J. Org. Chem., 69, 6907 (2004); https://doi.org/10.1021/jo049048b
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