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Vol. 33 No. 1 (2021): Vol 33 Issue 1

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Synthesis of Melamine Core Starburst Polyamide G1 Dendrimer and its Antibacterial and Antioxidant Activities

https://doi.org/10.14233/ajchem.2021.22991
Periyasamy Balu
Organic Synthesis and Nano Bio Laboratory, Department of Chemistry, Thiruvalluvar University, Vellore-632115, India
Indira Viswambaran Asharani
School of Advanced Science, VIT University, Vellore-632000, India
Dhakshamurthy Thirumalai
Organic Synthesis and Nano Bio Laboratory, Department of Chemistry, Thiruvalluvar University, Vellore-632115, India

Corresponding Author(s) : Dhakshamurthy Thirumalai

thirumalaid@tvu.edu.in

Asian Journal of Chemistry, Vol. 33 No. 1 (2021): Vol 33 Issue 1

Abstract

A novel polyamide first-generation dendrimer 7 was synthesized from new methodology under mild reaction conditions. The AB2 adduct, ethyl 2-[N-[2,2-bis(hydroxymethyl)propionyl]amino]ethylate (3), was prepared from 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) and glycine as a linker. Further, G1 dendrimer 7 was synthesized by coupling melamine (5) with monomer 3. The structural elucidations of all the compounds were confirmed by FTIR, 1H & 13C NMR and HRMS. The G1 dendrimer was found to exhibit significant antibacterial activity against S. aureus and E. cloacae and antioxidant activity by DPPH scavenging method when compared to the standard, ascorbic acid.

Keywords

Glycine ethyl ester hydrochloride Melamine 2,2-bis(Hydroxymethyl)propionic acid 2,2-Dimethoxypropane
Balu, P., Viswambaran Asharani, I., & Thirumalai, D. (2020). Synthesis of Melamine Core Starburst Polyamide G1 Dendrimer and its Antibacterial and Antioxidant Activities. Asian Journal of Chemistry, 33(1), 185–189. https://doi.org/10.14233/ajchem.2021.22991
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References
  1. D.A. Tomalia, Prog. Polym. Sci., 30, 294 (2005); https://doi.org/10.1016/j.progpolymsci.2005.01.007
  2. D. Jishkariani, C.M. MacDermaid, Y.N. Timsina, S. Grama, S.S. Gillani, M. Divar, S.S. Yadavalli, R.-O. Moussodia, P. Leowanawat, A.M. Berrios Camacho, R. Walter, M. Goulian, M.L. Klein and V. Percec, Proc. Natl.Acad. Sci. USA, 114, E2275 (2017); https://doi.org/10.1073/pnas.1700922114
  3. P. Stenström, E. Hjorth, Y. Zhang, O.C.J. Andrén, S. Guette-Marquet, M. Schultzberg and M. Malkoch, Biomacromolecules, 18, 4323 (2017); https://doi.org/10.1021/acs.biomac.7b01364
  4. W. Cao, J. Zhou, Y. Wang and L. Zhu, Biomacromolecules, 11, 3680 (2010); https://doi.org/10.1021/bm101154r
  5. E.M. Coma-Cros, A. Lancelot, M. San-Anselmo, L.N. Borgheti-Cardoso, J.J. Valle-Delgado, J.L. Serrano, X. Fernàndez-Busquets and T. Sierra, Biomater. Sci., 7, 1661 (2019); https://doi.org/10.1039/C8BM01600C
  6. E. Fedeli, A. Lancelot, J.M. Dominguez, J.L. Serrano, P. Calvo and T.Sierra, Nanomate., 9, 161 (2019); https://doi.org/10.3390/nano9020161
  7. W. Cao, J. Zhou, A. Mann, Y. Wang and L. Zhu, Biomacromolecules, 12, 2697 (2011); https://doi.org/10.1021/bm200487h
  8. M.T. McMahon and J.W.M. Bulte, WIREs Nanomed. Nanobiotechnol.,10, e1496 (2018); https://doi.org/10.1002/wnan.1496
  9. S. Alfei, S. Castellaro and G.B. Taptue, Org. Commun., 10, 144 (2017); https://doi.org/10.25135 acg.oc.22.17.06.034
  10. N. Bourne, L.R. Stanberry, E.R. Kern, G. Holan, B. Matthews and D.I. Bernstein, Antimicrob. Agents Chemother., 44, 2471 (2000); https://doi.org/10.1128/AAC.44.9.2471-2474.2000
  11. Y.H. Jiang, P. Emau, J.S. Cairns, L. Flanary, W.R. Morton, T.D.McCarthy and C.C. Tsai, AIDS Res. Hum. Retroviruses, 21, 207 (2005); https://doi.org/10.1089/aid.2005.21.207
  12. N. Fischer-Durand, M. Salmain, B. Rudolf, L. Jugé, V. Guérineau, O. Laprévote, A. Vessières and G. Jaouen, Macromolecules, 40, 8568(2007); https://doi.org/10.1021/ma071621g
  13. E.M. Coma-Cros, A. Lancelot, M.S. Anselmo, L.N. Borgheti-cardoso, J.J. Valle-Delgado, J.L. Serrano, X. Fernàndez-Busquets and T. Sierra, Biomater. Sci., 7, 1661 (2019); https://doi.org/10.1039/c8bm01600c
  14. A. Lancelot, R. González-Pastor, R. Clavería-Gimeno, P. Romero, O.Abian, P. Martín-Duque, J.L. Serrano and T. Sierra, J. Mater. Chem. B Mater. Biol. Med., 6, 3956 (2018); https://doi.org/10.1039/C8TB00639C
  15. L.X. Guo, Y.H. Liu, L. Wang, M. Wang, B.P. Lin and H. Yang, J. Mater.Chem. C Mater. Opt. Electron. Devices, 5, 9165 (2017); https://doi.org/10.1039/C7TC03059B
  16. S.B. Undre, M. Singh and R.K. Kale, J. Mol. Liq., 182, 106 (2013); https://doi.org/10.1016/j.molliq.2013.03.019
  17. E.D. Leriche, C. Afonso, C.M. Lange, M.C. Grossel, L. Truong, G. Coadou, H. Oulyadi and C. Loutelier-Bourhis, RSC Adv., 4, 1744 (2014); https://doi.org/10.1039/C3RA43939A
  18. M. Winnacker and B. Rieger, Polym. Chem., 7, 7039 (2016); https://doi.org/10.1039/C6PY01783E
  19. M. Endo, Y. Azuma, Y. Saga, A. Kuzuya, G. Kawai and M. Komiyama, J. Org. Chem., 62, 846 (1997);https://doi.org/10.1021/jo9611780
  20. M. Trollsås, J.L. Hedrick, D. Mecerreyes, P. Dubois, R. Jérôme, H.Ihre and A. Hult, Macromolecules, 31, 2756 (1998);https://doi.org/10.1021/ma971645v
  21. G. Carrot, J.G. Hilborn, M. Trollsås and J.L. Hedrick, Macromolecules, 32, 5264 (1999); https://doi.org/10.1021/ma990198b
  22. J. Ropponen, S. Nummelin and K. Rissanen, Org. Lett., 6, 2495 (2004); https://doi.org/10.1021/ol049555f
  23. A. Nazemi, T.B. Schon and E.R. Gillies, Org. Lett., 15, 1830 (2013); https://doi.org/10.1021/ol4004367
  24. S. Son and B.A. Lewis, J. Agric. Food Chem., 50, 468 (2002); https://doi.org/10.1021/jf010830b
  25. F. Malki, A. Touati and S. Moulay, J. Anal. Pharm. Res., 5, 00143 (2017); https://doi.org/10.15406/japlr.2017.05.00143
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