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Vol. 33 No. 1 (2021): Vol 33 Issue 1

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Antioxidant and Antidiabetic Activities of Flavonoid Derivative Compounds Isolated from Sclerocarya birrea Leaves

https://doi.org/10.14233/ajchem.2021.22909
Sithembiso L. Ndwandwe
Department of Biochemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa (Pretoria), South Africa
Mutendela T. Olivier
Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa (Pretoria), South Africa
Sechene S. Gololo
Department of Biochemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa (Pretoria), South Africa

Corresponding Author(s) : Sechene S. Gololo

Stanley.gololo@smu.ac.za

Asian Journal of Chemistry, Vol. 33 No. 1 (2021): Vol 33 Issue 1

Abstract

Sclerocarya birrea is one of many medicinal plants used in African traditional medicine for treatment of diabetes. Bioassay-guided fractionation of the ethanolic crude extract of the leaves of the plant species led to the isolation of a pure compound (CMP-1). The pure compound showed antioxidant and antidiabetic activities with average IC50 values of 1.04 mg/mL and 46 μg/mL, respectively that were well comparable to the crude extract and known standards compounds, ascorbic acid and quercetin. The spectroscopic profiling of the purified compound revealed a flavonoid derivative structural skeleton. The findings of the study suggested that the flavonoid derivative compounds play a major role towards the medicinal value of Sclerocarya birrea.

Keywords

Sclerocarya birrea Antioxidant activity Antidiabetic activity Flavonoid derivatives
L. Ndwandwe, S., T. Olivier, M., & S. Gololo, S. (2020). Antioxidant and Antidiabetic Activities of Flavonoid Derivative Compounds Isolated from Sclerocarya birrea Leaves. Asian Journal of Chemistry, 33(1), 57–61. https://doi.org/10.14233/ajchem.2021.22909
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