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Vol. 33 No. 12 (2021): Vol 33 Issue 12, 2021

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Bioactive Metal Complexes of Schiff Base Derived from 2,3-Dioxobutane, Ethane-1,2-diamine and 4-Chloro-2-formylphenol: Spectral Studies and in vitro Antimicrobial Activity

https://doi.org/10.14233/ajchem.2021.23478
Abhay Nanda srivastava
Department of Chemistry, Nitishwar Mahavidyalaya, (A constituent unit of B.R.A. Bihar University), Muzaffarpur-842002, India ; University Department of Chemistry, B.R.A. Bihar University, Muzaffarpur-842001, India
Sayanwita Panja
Department of Chemistry, Shahid Matangini Hazra Government General Degree College for Women, East Midnapore-721649, India
Netra Pal Singh
Department of Chemistry, Deen Dayal Upadhyay Gorakhpur University, Gorakhapur-273009, India
Chandra Kiran Shriwastaw
Department of Chemistry, Meerut College (Affiliated to C.C.S. University), Meerut-250001, India

Corresponding Author(s) : Abhay Nanda srivastava

abhay_s1986@yahoo.co.in

Asian Journal of Chemistry, Vol. 33 No. 12 (2021): Vol 33 Issue 12, 2021

Abstract

A novel series of trivalent coordination complexes was synthesized by the reaction between a chloride/acetate salt of iron, chromium, cobalt or manganese ions and NNNNOO type persuasive Schiff base ligand synthesized from 2,3-dioxobutane, ethane-1,2-diamine and 4-chloro-2-formylphenol. Synthesized compounds were characterized by using elemental analysis, molar conductance, magnetic moment, IR, UV-visible, 1H NMR, 13C NMR and ESI-MS spectral analyses. IR and NMR spectra favoured hexadentate coordination behaviour of ligand. Electronic spectra and magnetic moment data reveal Oh geometry with distortion around the metal ion in complexes. The molar conductance values show 1:1 electrolytic nature of complexes. Biological potentiality of the ligand and its metal complexes were tested in vitro against two bacterial and two fungal strains; Bacillus subtilis, Escherichia coli and Aspirgillus niger, Aspirgillus flavus, respectively.

Keywords

Schiff base Bioactive moieties Mononuclear complexes Antimicrobial potency
Nanda srivastava, A., Panja, S., Pal Singh, N., & Kiran Shriwastaw, C. (2021). Bioactive Metal Complexes of Schiff Base Derived from 2,3-Dioxobutane, Ethane-1,2-diamine and 4-Chloro-2-formylphenol: Spectral Studies and in vitro Antimicrobial Activity. Asian Journal of Chemistry, 33(12), 3063–3069. https://doi.org/10.14233/ajchem.2021.23478
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