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Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

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Antimicrobial and Drug Releasing Studies of Novel Acrylate Polymer based on Triazine

https://doi.org/10.14233/ajchem.2021.23018
P. Uma
R&D Centre, Bharathiar University, Coimbatore-641046, India ; P.G. & Research Department of Chemistry, Government Arts College, Tiruvannamalai-606603, India
J. Suresh
P.G. & Research Department of Chemistry, Government Arts College, Tiruvannamalai-606603, India
Revathi Selvaraj
R&D Centre, Bharathiar University, Coimbatore-641046, India
A. Arun
P.G. & Research Department of Chemistry, Government Arts College, Tiruvannamalai-606603, India

Corresponding Author(s) : A. Arun

aruna2075@yahoo.co.in

Asian Journal of Chemistry, Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

Abstract

This work is focused on the synthesis and characterization of versatile acrylate polymer of chalcone based triazine for their antibacterial activity and cumulative drug release behaviour studies. The novel acrylate monomer 4-(3-(4-((4-(4-(3-(4-((7-chloroquinolin-4-yl)amino)-phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)oxy)phenyl)-3-oxoprop-1-en-1-yl)phenylacrylate (SCP) is from novel chalcone and acryloyl chloride. Homo and copolymers of SCP were prepared using acrylic acid and hydroxyethyl acrylate. Physical characterization confirms the formation of the above compounds. Prepared drug molecules possess chalcone moiety as well as quinoline so it has the greater effect to inhibit the growth of the Gram-negative bacteria (15.63 ± 0.4 μg/mL) was confirmed by MIC method. The weight average molecular weight of the polymer is 10,000 g/mol. The polymer decomposes at 325 ºC. Drug releasing in vitro behaviour of the synthesized drug is controlled by the nature of comonomer, pH and the temperature.

Keywords

Quinoline Chalcone Acrylate Polymer Drug delivery Antimicrobial activity
Uma, P., Suresh, J., Selvaraj, R., & Arun, A. (2021). Antimicrobial and Drug Releasing Studies of Novel Acrylate Polymer based on Triazine. Asian Journal of Chemistry, 33(11), 2707–2714. https://doi.org/10.14233/ajchem.2021.23018
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