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Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

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Spectral and Electrochemical Sensing Studies of Unsymmetrical Schiff Bases having Enhanced Antifungal Activity

https://doi.org/10.14233/ajchem.2021.23351
Selvaraj Shunmugaperumal
PG & Research Department of Chemistry, Government Arts College for Men (Autonomous), Nandanam, Chennai-600035, India
Saranya Dhasarathan
PG & Research Department of Chemistry, Government Arts College for Men (Autonomous), Nandanam, Chennai-600035, India
Kamatchi Selvaraj P
PG & Research Department of Chemistry, Government Arts College for Men (Autonomous), Nandanam, Chennai-600035, India
Ilango Kaliappan
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, India
Bathula Siva Kumar
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, India

Corresponding Author(s) : Kamatchi Selvaraj P

porbal96@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

Abstract

Novel unsymmetrical Schiff bases comprising azomethine spin-off having ferrocene moiety at one end and simple aromatic component attached imine at other end, capable of sensing multiple metal ions have been synthesized. The MLCT charge transfer band in UV-Visible studies upon coordination with metal ions with receptors is recorded particularly for Cu2+ ions. The observed ΔEp values with change in scan rate for metal free and metal added receptor solution suggest quasi-reversible process. Agar well diffusion method and molecular docking studies reveals that the synthesized compounds inhibit more efficiently fungi rather than bacteria, which hampers the progress of microbial research, as the available antifungal agents are minimal compared to antibacterial counterpart.

Keywords

Unsymmetrical Schiff bases Azomethine Ferrocene Cation sensors Binding attitude Molecular docking
Shunmugaperumal, S., Dhasarathan, S., Selvaraj P, K., Kaliappan, I., & Siva Kumar, B. (2021). Spectral and Electrochemical Sensing Studies of Unsymmetrical Schiff Bases having Enhanced Antifungal Activity. Asian Journal of Chemistry, 33(10), 2400–2410. https://doi.org/10.14233/ajchem.2021.23351
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