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Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

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Design, Synthesis and Biological Evaluation of Novel Thiazolidinone Derivatives

https://doi.org/10.14233/ajchem.2021.23337
Reshma Sathyanarayana
Department of Chemistry, Mangalore University, Mangalagangothri-574199, India
Boja Poojary
Department of Chemistry, Mangalore University, Mangalagangothri-574199, India
B. Sukesh Kumar
Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Mangalore-575018, India
Vasantha Kumar
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India
Rajesh P. Shastry
Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Mangalore-575018, India
Shamprasad Varija Raghu
Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri-574199, India

Corresponding Author(s) : Boja Poojary

poojaryboja@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

Abstract

In present study, the novel thiazolidinone derivatives were designed and synthesized. The formation of the target compounds was confirmed by the elemental analyses, FT-IR, mass spectroscopy and 1H NMR spectroscopy. These derivatives were subjected to antibacterial and antioxidant activities. The antibacterial results revealed that these derivatives were selectively active against Gram-negative Pseudomonas aeruginosa bacteria. Also, these derivatives displayed a good DPPH radical scavenging effect. Drosophila melanogaster flies were used for evaluating the toxic impact of novel thiazolidinone derivatives.

Keywords

Thiazolidinone Vanillin Antibacterial activity Antioxidant activity Drosophila melanogaster
Sathyanarayana, R., Poojary, B., Sukesh Kumar, B., Kumar, V., P. Shastry, R., & Varija Raghu, S. (2021). Design, Synthesis and Biological Evaluation of Novel Thiazolidinone Derivatives. Asian Journal of Chemistry, 33(10), 2379–2385. https://doi.org/10.14233/ajchem.2021.23337
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