Copyright (c) 2025 Norhayati Muhammad

This work is licensed under a Creative Commons Attribution 4.0 International License.
Exploring the Phytochemical Potential of Erythrina Species: A Review on Extraction Methods and Bioactive Properties
Corresponding Author(s) : N. Muhammad
Asian Journal of Chemistry,
Vol. 37 No. 8 (2025): Vol 37 Issue 8, 2025
Abstract
Erythrina species, are well-known for their abundance of medicinal properties such as antioxidant, anti-inflammatory, antibacterial and anticancer due to their bioactive compounds. This article aims to provide a brief review on the impact of different extraction methods, from traditional techniques (e.g. Soxhlet extraction; maceration), to newer and more eco-friendly approaches (e.g. ultrasound-assisted extraction (UAE); microwave-assisted extraction (MAE)) on the bioactivities. A review was done using databases such as PubMed, Scopus, Web of Science and Google Scholar, searching for terms like Erythrina genus, extraction method, extraction conditions, phytochemicals and bioactivities. As a result, 5 different extraction methods were found to be the most frequently used for extraction of Erythrina species, which are Soxhlet extraction, maceration, decoction, UAE and MAE. It was also showed that UAE and MAE are the most ideal extraction techniques as it improved extraction efficiency, preserve bioactive compounds and increased bioactivity retention. Hence, this mini-review is a discussion on the influence of extraction condition such as extraction temperature and extraction time that may affect the bioactivity of Erythrina species from the previous studies.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- N.M. Fahmy, E. Al-Sayed, M. El-Shazly and A. Nasser Singab, Nat. Prod. Res., 34, 1891 (2020); https://doi.org/10.1080/14786419.2018.1564300
- E. Susilawati, J. Levita, Y. Susilawati and S.A. Sumiwi, Front. Pharmacol., 14, 1281150 (2023); https://doi.org/10.3389/fphar.2023.1281150
- N.T. Son and A.I. Elshamy, Comb. Chem. High Throughput Screen., 24, 20 (2021); https://doi.org/10.2174/1386207323666200609141517
- T. Jiménez-Cabrera, M. Bautista, C. Velázquez-González, O.A. Jaramillo-Morales, J.A. Guerrero-Solano, T.A. Urrutia-Hernández and M. De la O-Arciniega, Int. J. Mol. Sci., 22, 248 (2020); https://doi.org/10.3390/ijms22010248
- N.M. Fahmy, E. Al-Sayed, H.E. Michel, M. El-Shazly and A.N.B. Singab, J. Ethnopharmacol., 248, 112297 (2020); https://doi.org/10.1016/j.jep.2019.112297
- S.B. Obakiro, A. Kiprop, E. Kigondu, I. K’Owino, M.P. Odero, S. Manyim, T. Omara, J. Namukobe, R.O. Owor, Y. Gavamukulya and L. Bunalema, Evid. Based Complement. Alternat. Med., 2021, 513484 (2021); https://doi.org/10.1155/2021/5513484
- T.L. Adetunji, M.A. Acho, V.O. Samuel, C.R. Ohoro and M. Ramulondi, J. Ethnopharmacol., 319, 117273 (2024); https://doi.org/10.1016/j.jep.2023.117273
- A. Jurinjak Tušek, D. Šamec and A. Šalic, Appl. Sci., 12, 11865 (2022); https://doi.org/10.3390/app122211865
- A. Weremfo, S. Abassah-Oppong, F. Adulley, K. Dabie and S. Seidu-Larry, J. Sci. Food Agric., 103, 26 (2023); https://doi.org/10.1002/jsfa.12121
- M. Mosic, A. Dramicanin, P. Ristivojevic and D. Milojkovic-Opsenica, J. AOAC Int., 103, 365 (2020); https://doi.org/10.5740/jaoacint.19-0251
- P.A. Uwineza and A. Wackiewicz, Molecules, 25, 3847 (2020); https://doi.org/10.3390/molecules25173847
- R. Direito, S.M. Barbalho, B. Sepodes and M.E. Figueira, Pharmaceutics, 16, 577 (2024); https://doi.org/10.3390/pharmaceutics16050577
- M. Usman, M. Nakagawa and S. Cheng, Processes, 11, 3444 (2023); https://doi.org/10.3390/pr11123444
- A. Najmi, S.A. Javed, M. Al Bratty and H.A. Alhazmi, Molecules, 27, 349 (2022); https://doi.org/10.3390/molecules27020349
- J.S. Câmara, B.R. Albuquerque, J. Aguiar, R.C. Corrêa, J.L. Gonçalves, D. Granato, J.A.M. Pereira, L. Barros and I.C.F.R. Ferreira, Foods, 10, 37 (2020); https://doi.org/10.3390/foods10010037
- P.P. Paikrao, A.M. Wankhade, V.V. Paithankar, J.V. Vyas and S.A. Bhagat, Int. J. Creat. Res. Thoughts, 10, 392 (2022).
- R. Guedes-Oliveira, A.P. Fortuna-Perez, L.C. Pederneiras and V.F. Mansano, PhytoKeys, 232, 1 (2023); https://doi.org/10.3897/phytokeys.232.101105
- N.M. Fahmy, E. Al-Sayed, M. El-Shazly and A.N. Singab, Ind. Crops Prod., 123, 500 (2018); https://doi.org/10.1016/j.indcrop.2018.06.028
- C. Bitwell, S.S. Indra, C. Luke and M.K. Kakoma, Sci. African, 19, e01585 (2023); https://doi.org/10.1016/j.sciaf.2023.e01585
- S.P. Patil, A. Jain and A.S. Kakad, J. Compr. Adv. Pharmacol, 9, 7 (2024); https://doi.org/10.31024/apj.2024.9.1.2
- E. Susilawati, W. Aligita, M. Kaniawati, D.A. Liani, Y. Susilawati, J. Levita and S.A. Sumiwi, J. Appl. Pharm. Sci., 14, 291 (2023); https://doi.org/10.7324/JAPS.2024.141692
- A. Antony and M. Farid, Appl. Sci., 12, 2107 (2022); https://doi.org/10.3390/app12042107
- D.S. Silva, A.C. Garcia, S.S. Mata, B.D. Oliveira, C.S. Estevam, R. Scher and S.M. Pantaleao, Rev. Bras. Farmacogn., 21, 92 (2011); https://doi.org/10.1590/S0102-695X2011005000024
- P. Barik, K. Dagar, R. Makhija, A. Singh and V.A. Asati, Curr. Anal. Chem., 21, 79 (2025); https://doi.org/10.2174/0115734110296570240422063010
- K. Kumar, S. Srivastav and V.S. Sharanagat, Ultrason. Sonochem., 70, 105325 (2021); https://doi.org/10.1016/j.ultsonch.2020.105325
- A. Carreira-Casais, P. Otero, P. Garcia-Perez, P. Garcia-Oliveira, A.G. Pereira, M. Carpena, A. Soria-Lopez, J. Simal-Gandara and M.A. Prieto, Int. J. Environ. Res. Public Health, 18, 9153 (2021); https://doi.org/10.3390/ijerph18179153
- Y.K. Mohanta, S.K. Panda, R. Jayabalan, N. Sharma, A.K. Bastia and T.K. Mohanta, Front. Mol. Biosci., 4, 14 (2017); https://doi.org/10.3389/fmolb.2017.00014
- C.S. Dzah, Y. Duan, H. Zhang, C. Wen, J. Zhang, G. Chen and H. Ma, Food Biosci., 35, 100547 (2020); https://doi.org/10.1016/j.fbio.2020.100547
- A. Kumar and M.G. Khan, SSRN Electron J., June 1 (2019); https://doi.org/10.2139/ssrn.3557317
- B. de Almeida Andrade, A.J.C. Corrêa, A.K.S. Gomes, P.M. da Silva Neri Cruz, A.M. de Saint-George Albuquerque Cheron, V.T.N. de Almeidae Castro, D.H.A.S. de Mello, C.S. de Andrade Lima, R. Yara and E.L.C. de Amorim, J. Biosci. Med., 11, 325 (2023); https://doi.org/10.4236/jbm.2023.1112025
- A. Das, S. Basak, S. Chakraborty and M. Dhibar, Curr. Anal. Chem., 18, 858 (2022); https://doi.org/10.2174/1573411018666220527095408
- E. Pogorzelska-Nowicka, M. Hanula and G. Pogorzelski, Food Chem., 460, 140456 (2024); https://doi.org/10.1016/j.foodchem.2024.140456
- M.M. Ramesh, N.S. Shankar and A.H. Venkatappa, Pharmacogn. Rev., 18, 68 (2024); https://doi.org/10.5530/phrev.2024.18.7
- K. Selvaraj, P. Theivendren, P. Pavadai, R.P. Sureshbabu, V. Ravishankar, P. Palanisamy, M. Gopal, S.R. Dharmalingam and M. Sankaranarayanan, Curr. Bioact. Compd., 18, 11 (2022); https://doi.org/10.2174/1573407217666210525143836
- R. Rahmawati, Y.W. Hartati, J. Latip and T. Herlina, J. Sep. Sci., 46, e2200800 (2023); https://doi.org/10.1002/jssc.202200800
- R. ElGamal, C. Song, A.M. Rayan, C. Liu, S. Al-Rejaie and G. ElMasry, Agronomy, 13, 1580 (2023); https://doi.org/10.3390/agronomy13061580
- C.-H. Wong, Temperature Effects. In: Catalysis from A to Z, Wiley (2020); https://doi.org/10.1002/9783527809080.cataz16415
References
N.M. Fahmy, E. Al-Sayed, M. El-Shazly and A. Nasser Singab, Nat. Prod. Res., 34, 1891 (2020); https://doi.org/10.1080/14786419.2018.1564300
E. Susilawati, J. Levita, Y. Susilawati and S.A. Sumiwi, Front. Pharmacol., 14, 1281150 (2023); https://doi.org/10.3389/fphar.2023.1281150
N.T. Son and A.I. Elshamy, Comb. Chem. High Throughput Screen., 24, 20 (2021); https://doi.org/10.2174/1386207323666200609141517
T. Jiménez-Cabrera, M. Bautista, C. Velázquez-González, O.A. Jaramillo-Morales, J.A. Guerrero-Solano, T.A. Urrutia-Hernández and M. De la O-Arciniega, Int. J. Mol. Sci., 22, 248 (2020); https://doi.org/10.3390/ijms22010248
N.M. Fahmy, E. Al-Sayed, H.E. Michel, M. El-Shazly and A.N.B. Singab, J. Ethnopharmacol., 248, 112297 (2020); https://doi.org/10.1016/j.jep.2019.112297
S.B. Obakiro, A. Kiprop, E. Kigondu, I. K’Owino, M.P. Odero, S. Manyim, T. Omara, J. Namukobe, R.O. Owor, Y. Gavamukulya and L. Bunalema, Evid. Based Complement. Alternat. Med., 2021, 513484 (2021); https://doi.org/10.1155/2021/5513484
T.L. Adetunji, M.A. Acho, V.O. Samuel, C.R. Ohoro and M. Ramulondi, J. Ethnopharmacol., 319, 117273 (2024); https://doi.org/10.1016/j.jep.2023.117273
A. Jurinjak Tušek, D. Šamec and A. Šalic, Appl. Sci., 12, 11865 (2022); https://doi.org/10.3390/app122211865
A. Weremfo, S. Abassah-Oppong, F. Adulley, K. Dabie and S. Seidu-Larry, J. Sci. Food Agric., 103, 26 (2023); https://doi.org/10.1002/jsfa.12121
M. Mosic, A. Dramicanin, P. Ristivojevic and D. Milojkovic-Opsenica, J. AOAC Int., 103, 365 (2020); https://doi.org/10.5740/jaoacint.19-0251
P.A. Uwineza and A. Wackiewicz, Molecules, 25, 3847 (2020); https://doi.org/10.3390/molecules25173847
R. Direito, S.M. Barbalho, B. Sepodes and M.E. Figueira, Pharmaceutics, 16, 577 (2024); https://doi.org/10.3390/pharmaceutics16050577
M. Usman, M. Nakagawa and S. Cheng, Processes, 11, 3444 (2023); https://doi.org/10.3390/pr11123444
A. Najmi, S.A. Javed, M. Al Bratty and H.A. Alhazmi, Molecules, 27, 349 (2022); https://doi.org/10.3390/molecules27020349
J.S. Câmara, B.R. Albuquerque, J. Aguiar, R.C. Corrêa, J.L. Gonçalves, D. Granato, J.A.M. Pereira, L. Barros and I.C.F.R. Ferreira, Foods, 10, 37 (2020); https://doi.org/10.3390/foods10010037
P.P. Paikrao, A.M. Wankhade, V.V. Paithankar, J.V. Vyas and S.A. Bhagat, Int. J. Creat. Res. Thoughts, 10, 392 (2022).
R. Guedes-Oliveira, A.P. Fortuna-Perez, L.C. Pederneiras and V.F. Mansano, PhytoKeys, 232, 1 (2023); https://doi.org/10.3897/phytokeys.232.101105
N.M. Fahmy, E. Al-Sayed, M. El-Shazly and A.N. Singab, Ind. Crops Prod., 123, 500 (2018); https://doi.org/10.1016/j.indcrop.2018.06.028
C. Bitwell, S.S. Indra, C. Luke and M.K. Kakoma, Sci. African, 19, e01585 (2023); https://doi.org/10.1016/j.sciaf.2023.e01585
S.P. Patil, A. Jain and A.S. Kakad, J. Compr. Adv. Pharmacol, 9, 7 (2024); https://doi.org/10.31024/apj.2024.9.1.2
E. Susilawati, W. Aligita, M. Kaniawati, D.A. Liani, Y. Susilawati, J. Levita and S.A. Sumiwi, J. Appl. Pharm. Sci., 14, 291 (2023); https://doi.org/10.7324/JAPS.2024.141692
A. Antony and M. Farid, Appl. Sci., 12, 2107 (2022); https://doi.org/10.3390/app12042107
D.S. Silva, A.C. Garcia, S.S. Mata, B.D. Oliveira, C.S. Estevam, R. Scher and S.M. Pantaleao, Rev. Bras. Farmacogn., 21, 92 (2011); https://doi.org/10.1590/S0102-695X2011005000024
P. Barik, K. Dagar, R. Makhija, A. Singh and V.A. Asati, Curr. Anal. Chem., 21, 79 (2025); https://doi.org/10.2174/0115734110296570240422063010
K. Kumar, S. Srivastav and V.S. Sharanagat, Ultrason. Sonochem., 70, 105325 (2021); https://doi.org/10.1016/j.ultsonch.2020.105325
A. Carreira-Casais, P. Otero, P. Garcia-Perez, P. Garcia-Oliveira, A.G. Pereira, M. Carpena, A. Soria-Lopez, J. Simal-Gandara and M.A. Prieto, Int. J. Environ. Res. Public Health, 18, 9153 (2021); https://doi.org/10.3390/ijerph18179153
Y.K. Mohanta, S.K. Panda, R. Jayabalan, N. Sharma, A.K. Bastia and T.K. Mohanta, Front. Mol. Biosci., 4, 14 (2017); https://doi.org/10.3389/fmolb.2017.00014
C.S. Dzah, Y. Duan, H. Zhang, C. Wen, J. Zhang, G. Chen and H. Ma, Food Biosci., 35, 100547 (2020); https://doi.org/10.1016/j.fbio.2020.100547
A. Kumar and M.G. Khan, SSRN Electron J., June 1 (2019); https://doi.org/10.2139/ssrn.3557317
B. de Almeida Andrade, A.J.C. Corrêa, A.K.S. Gomes, P.M. da Silva Neri Cruz, A.M. de Saint-George Albuquerque Cheron, V.T.N. de Almeidae Castro, D.H.A.S. de Mello, C.S. de Andrade Lima, R. Yara and E.L.C. de Amorim, J. Biosci. Med., 11, 325 (2023); https://doi.org/10.4236/jbm.2023.1112025
A. Das, S. Basak, S. Chakraborty and M. Dhibar, Curr. Anal. Chem., 18, 858 (2022); https://doi.org/10.2174/1573411018666220527095408
E. Pogorzelska-Nowicka, M. Hanula and G. Pogorzelski, Food Chem., 460, 140456 (2024); https://doi.org/10.1016/j.foodchem.2024.140456
M.M. Ramesh, N.S. Shankar and A.H. Venkatappa, Pharmacogn. Rev., 18, 68 (2024); https://doi.org/10.5530/phrev.2024.18.7
K. Selvaraj, P. Theivendren, P. Pavadai, R.P. Sureshbabu, V. Ravishankar, P. Palanisamy, M. Gopal, S.R. Dharmalingam and M. Sankaranarayanan, Curr. Bioact. Compd., 18, 11 (2022); https://doi.org/10.2174/1573407217666210525143836
R. Rahmawati, Y.W. Hartati, J. Latip and T. Herlina, J. Sep. Sci., 46, e2200800 (2023); https://doi.org/10.1002/jssc.202200800
R. ElGamal, C. Song, A.M. Rayan, C. Liu, S. Al-Rejaie and G. ElMasry, Agronomy, 13, 1580 (2023); https://doi.org/10.3390/agronomy13061580
C.-H. Wong, Temperature Effects. In: Catalysis from A to Z, Wiley (2020); https://doi.org/10.1002/9783527809080.cataz16415