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Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Copyright (c) 2025 Sangeeta Korane

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Novel Cu(II) Complexes of 3,5-Di-tert-butyl-2-hydroxy benzylidene-2-aminobenzhydrazide: Synthesis, Spectral Characterization, Antimicrobial and Antioxidant Properties

https://doi.org/10.14233/ajchem.2025.33650
Sangeeta Korane
Department of Chemistry, Rajarshi Chhatrapati Shahu College, Kolhapur-416005, India
https://orcid.org/0000-0002-2786-1201
Babasaheb Bhosale
Department of Chemistry, Rajaram College, Kolhapur-416004, India
https://orcid.org/0009-0000-5812-9817

Corresponding Author(s) : Sangeeta Korane

koranesangeeta9@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Abstract

The present study reports the synthesis and characterization of three copper(II) complexes of novel hydrazone ligand 3,5-di-tert-butyl 2-hydroxy benzylidene 2-aminobenzhydrazide [H2L]. The complexes viz. [Cu(HL)(Cl2)H2O] (1a), [Cu(HL)(NO3)]·2/3H2O (2a), [{Cu(HL)}2(µ-SO4)]·11/3H2O (3a) and ligand (H2L) were characterized by elemental analysis, spectroscopic techniques (FT-IR, 1H NMR, 13C NMR, UV-visible, LC-MS and PXRD), molar conductance, magnetic susceptibility measurement and thermal analysis. Thermal data of complexes at different temperatures provides the valuable information about different fragments of structure, their molecular weights, thermal stability, coordinated and fractional number of lattice water molecules in the synthesized metal complexes. Complex 1a exhibit distorted octahedral geometry, whereas complexes 2a and 3a exhibit square planer to square pyramidal geometry inferred from magnetic, electronic and spectroscopic data. In all the complexes, the ligand coordinate to metal in tridentate mode through the ONO [OKetonic, Nazomethine and Ophenolic] chelating system. The antibacterial potential of synthesized molecules have been determined against Gram+ve and Gram-ve bacteria Bacillus subtilis, Bacillus cereus, Escherichia coli, Pseudomonas vulgaris, Staphylococcus aureus, etc. The antioxidant activity was also determined using DPPH radical scavenging assay. It is clear that the new complexes are good active compounds for use in a variety of applications.

Keywords

Copper(II) complexes Hydrazone Antimicrobial activity Antioxidant activity Square pyramidal Thermal studies
(1)
Korane, S.; Bhosale, B. Novel Cu(II) Complexes of 3,5-Di-Tert-Butyl-2-Hydroxy Benzylidene-2-Aminobenzhydrazide: Synthesis, Spectral Characterization, Antimicrobial and Antioxidant Properties. ajc 2025, 37, 1176-1182.
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