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Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025

Copyright (c) 2025 Kishore Ravada, Sreenivas sunkara, Praveen Kumar Edigi, Ananda Kumar Jami, Sivaramakrishna Dokku

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Characterization of Novel 1,2,3-Triazole linked Quinoline-based Thiazolidine-2,4-dione Derivatives as Potential Anticancer Agents and their Molecular Docking Studies

https://doi.org/10.14233/ajchem.2025.33432
Sreenivas Sunkara
Department of Chemistry, School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0009-0009-6419-8881
Ravada Kishore
Department of Chemistry, School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0000-0002-7570-8447
Praveen Kumar Edigi
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-9418-508X
Ananda Kumar Jami
Department of Chemistry, Godavari Global University, Rajahmundry-533296, India
https://orcid.org/0009-0000-0081-9460
Dokku Sivaramakrishna
Department of Chemistry, School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0000-0002-1256-8096

Corresponding Author(s) : Ravada Kishore

kravada@gitam.edu

Asian Journal of Chemistry, Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025

Abstract

Novel hybrid molecules incorporating 1,2,3-triazole linked quinoline-based thiazolidine-2,4-dione derivatives (9a-l) were synthesized and validated through various 1H NMR, 13C NMR and ESI-MS. All the synthesized hybrid compounds were assessed for their anticancer activity against two cancer cell lines, MCF-7 and HEPG2, utilizing the MTT assay with doxorubicin as the standard reference drug. In comparison to the standard, compounds 9l, 9h, 9k, 9d and 9b exhibited superior activity against the tested cancer cell lines, MCF-7 and HEPG2. Additionally, molecular docking studies were conducted on the novel derivatives 9a-l against dihydrofolate reductase (DHFR), revealing a correlation between the molecular docking results and the observed anticancer activity.

Keywords

1,2,3-Triazole Quinoline Thiazolidine-2,4-dione Anticancer activity Molecular docking studies
Sunkara, S., Kishore, R., Edigi, P. K., Jami, A. K., & Sivaramakrishna, D. (2025). Synthesis and Characterization of Novel 1,2,3-Triazole linked Quinoline-based Thiazolidine-2,4-dione Derivatives as Potential Anticancer Agents and their Molecular Docking Studies. Asian Journal of Chemistry, 37(3), 722–728. https://doi.org/10.14233/ajchem.2025.33432
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