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Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Copyright (c) 2025 Chandima Shashikala Kumari Rajapakse, Lakshika Jayawardhana, Darshani Dewage

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Ethanolic Extract of Terminalia catappa Kernel: A Natural Remedy with Promising Pharmacological Potential

https://doi.org/10.14233/ajchem.2025.33323
H.A.L.D. Jayawardhana
Department of Chemistry, University of Kelaniya, Kelaniya, Sri Lanka
https://orcid.org/0009-0007-5318-1633
D.H.D. DewageDona
Department of Chemistry, University of Kelaniya, Kelaniya, Sri Lanka
https://orcid.org/0000-0003-1304-2333
C.S.K. Rajapakse
Department of Chemistry, University of Kelaniya, Kelaniya, Sri Lanka
https://orcid.org/0000-0002-1340-7331

Corresponding Author(s) : C.S.K. Rajapakse

shashikala@kln.ac.lk

Asian Journal of Chemistry, Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Abstract

A relationship between humans and nature began with our ancestral reliance on natural resources for survival and health. This relationship has profoundly influenced the field of pharmacology through the discovery and utilization of natural product drugs, demonstrating the enduring importance of nature in medicine and the ongoing exploration of its therapeutic potential. This study investigates the pharmacological potential of the ethanolic extract of Ceylon almond kernel (Terminalia catappa), highlighting its antioxidant (IC50 = 21.68 ± 1.97 µg/mL), anti-inflammatory (IC50 = 180.14 ± 3.99 µg/mL) and α-amylase inhibitory (IC50 = 147.77 ± 4.74 µg/mL) activities. It also showed antibacterial activity against various pathogens and minimal UV protection (SPF = 5.27 ± 0.63). These results suggest that the Ceylon almond kernel could be a promising natural source for pharmaceutical applications and drug development.

Keywords

Antibacterial activity Anti-inflammatory activity α-Amylase inhibitory Sun protection factor Terminalia catappa
(1)
Jayawardhana, H.; DewageDona, D.; Rajapakse, C. Ethanolic Extract of Terminalia Catappa Kernel: A Natural Remedy With Promising Pharmacological Potential. ajc 2025, 37, 758-764.
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