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Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Copyright (c) 2025 Kavitha R Thirumoorthi, Swapna M. Gali, Jagadeswaran S., Jayaprakash G.K. , Kiran Kumar Tadi

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Development of Reduced Graphene Oxide Ionic Liquid Nanocomposite for the Electrochemical Sensing of Uric Acid

https://doi.org/10.14233/ajchem.2025.33321
Kavitha R. Thirumoorthi
Energy, Electrodics and Electrocatalysis (EEE) Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Chennai-600127, India
https://orcid.org/0009-0007-6729-4356
Swapna M. Gali
Department of Physics, Academy of Maritime Education and Training, Chennai-603112, India
https://orcid.org/0000-0003-3857-0773
S. Jagadeswaran
Energy, Electrodics and Electrocatalysis (EEE) Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Chennai-600127, India
https://orcid.org/0009-0001-2419-9937
G.K. Jayaprakash
Department of Chemistry, Nitte Meenakshi Institute of Technology, Bangalore-560064, India
https://orcid.org/0000-0003-0681-7815
Kiran Kumar Tadi
Energy, Electrodics and Electrocatalysis (EEE) Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Chennai-600127, India
https://orcid.org/0000-0002-8647-9379

Corresponding Author(s) : Kiran Kumar Tadi

kirankumar.tadi@vit.ac.in

Asian Journal of Chemistry, Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Abstract

Graphene-based biosensors are garnering significant scholarly interest attributable to the engineering potential of graphene, which enhances both specificity and sensitivity. However, pristine graphene doesn’t account for any specific interactions. The research investigates the utilization of reduced graphene oxide (rGO) in conjunction with hexylmethyl imidazolium tetrafluoroborate ([HMIM]/[BF4]) ionic liquid (IL) modified glassy carbon electrodes (GCE) for the electrochemical detection of uric acid. Graphene oxide (GO) was synthesized using the improved Hummer’s method. Raman spectra was recorded to confirm the exfoliation of graphite to GO and reduction of GO. Cyclic voltammetry and electrochemical impedance spectroscopy were used to study the electron transfer kinetics of the modified electrode. The linearity range of the fabricated sensor was recorded using differential pulse voltammetry (DPV) and observed linearity from 19.6 × 10–6 M to 1.6 × 10–2 M of uric acid concentration with a detection limit of 5.1 × 10–6 M using differential pulse voltammetry (DPV).

Keywords

Uric acid Electrochemical sensors Reduced graphene oxide Ionic liquid
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Thirumoorthi, K. R.; Gali, S. M.; Jagadeswaran, S.; Jayaprakash, G.; Tadi, K. K. Development of Reduced Graphene Oxide Ionic Liquid Nanocomposite for the Electrochemical Sensing of Uric Acid. ajc 2025, 37, 1134-1140.
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References
  1. J. Maiuolo, F. Oppedisano, S. Gratteri, C. Muscoli and V. Mollace, Int. J. Cardiol., 213, 8 (2016); https://doi.org/10.1016/j.ijcard.2015.08.109
  2. D. Swinson, J. Snaith, J. Buckberry and M. Brickley, Int. J. Osteoarchaeol., 20, 135 (2010); https://doi.org/10.1002/oa.1009
  3. N. Duplancic, D. Kukoc-Modun, L. Modun and D. Radic, Molecules, 16, 7058 (2011); https://doi.org/10.3390/molecules16087058
  4. F.R.P. Rocha and D.L. Rocha, Microchem. J., 94, 53 (2010); https://doi.org/10.1016/j.microc.2009.08.010
  5. M.L. Jin, D. Seo, M.H. Huy, B.T. Pham, Q.T. Conte, Y.-I. Thangadurai and D. Lee, Biosens. Bioelectron., 77, 359 (2016); https://doi.org/10.1016/j.bios.2015.09.057
  6. Z. Zhang, Y. Jin, X. Li, J. Zhao, X. Guo, J. Wang, Z. Guo, X. Zhang, Y. Tao, Y. Liu, D. Chen and X. Liang, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1026, 67 (2016); https://doi.org/10.1016/j.jchromb.2015.11.015
  7. M.B. Blauch and F.C. Koch, J. Biol. Chem., 130, 443 (1939); https://doi.org/10.1016/S0021-9258(18)73516-3
  8. G. Li, C. Xu, H. Xu, L. Gan, K. Sun and B. Yuan, Analyst, 148, 2553 (2023); https://doi.org/10.1039/D3AN00291H
  9. Geethukrishnan, O. Apte and K.K. Tadi, Tungsten, 7, 137 (2024); https://doi.org/10.1007/s42864-024-00297-7
  10. C. Wang, P. Xu and K. Zhuo, Anal. Sci., 26, 191 (2014); https://doi.org/10.1002/elan.201300345
  11. M. Pumera, Chem. Rec., 9, 211 (2009); https://doi.org/10.1002/tcr.200900008
  12. D. Li, J. Liu, C.J. Barrow and W. Yang, Chem. Commun., 50, 8197 (2014); https://doi.org/10.1039/c4cc03384a
  13. S. Xu, T. Wang, G. Liu, Z. Cao, L.A. Frank, S. Jiang, C. Zhang, Z. Li, V.V. Krasitskaya, Q. Li, Y. Sha, X. Zhang, H. Liu and J. Wang, Sens. Actuators B Chem., 326, 128991 (2021); https://doi.org/10.1016/j.snb.2020.128991
  14. A.R. Jalalvand and M.M. Karami, Sens. Bio-Sens. Res., 47, 100733 (2025); https://doi.org/10.1016/j.sbsr.2024.100733
  15. N. Mushahary, A. Sarkar, F. Basumatary, S. Brahma, B. Das and S. Basumatary, Result Surfaces Interfaces, 15, 10025 (2024); https://doi.org/10.1016/j.rsurfi.2024.100225
  16. S.S. Sekhon, P. Kaur, Y.H. Kim and S.S. Sekhon, npj 2D Mater. Appl., 5, 21 (2021); https://doi.org/10.1038/s41699-021-00202-7
  17. J. Liu, C. Shuping, L. Yanan and Z. Bijing, J. Saudi Chem. Soc., 26, 101560 (2022); https://doi.org/10.1016/j.jscs.2022.101560
  18. P.L. Yap, S. Kabiri, Y.L. Auyoong, D.N.H. Tran and D. Losic, ACS Omega, 4, 19505 (2019); https://doi.org/10.1021/acsomega.9b02642
  19. P. Klemp, S.A. Stansfield, B. Castle and M.C. Robertson, Ann. Rheum. Dis., 56, 22 (1997); https://doi.org/10.1136/ard.56.1.22
  20. D. Isin, E. Eksin and A. Erdem, Biosensors, 12, 95 (2022); https://doi.org/10.3390/bios12020095
  21. K. Chen, B. Xu, L. Shen, D. Shen, M. Li and L.-H. Guo, RSC Adv., 12, 19452 (2022); https://doi.org/10.1039/D2RA02547G
  22. P. Kumar, I. Soni, G.K. Jayaprakash, S. Kumar, S. Rao, R. Flores-Moreno and A.S. Sowmyashree, Inorg. Chem. Commun., 146, 110110 (2022); https://doi.org/10.1016/j.inoche.2022.110110
  23. D.C. Marcano, D.V. Kosynkin, J.M. Berlin, A. Sinitskii, A. Slesarev, Z. Sun, L.B. Alemany, W. Lu and J.M. Tour, ACS Nano, 4, 4806 (2010); https://doi.org/10.1021/nn1006368
  24. N. Murugesan, M. Kandasamy, S. Murugesan, N. Pugazhenthiran, S. Suresh, V.P. Venkatesh, B.K. Balachandar, S.K. Kumar and M.N.M. Ansari, Physica B, 669, 415288 (2023); https://doi.org/10.1016/j.physb.2023.415288
  25. A.C. Ferrari and D.M. Basko, Nat. Nanotechnol., 8, 235 (2013); https://doi.org/10.1038/nnano.2013.46
  26. S.I. Khan, K.K. Tadi, R.R. Chillawar and R.V. Motghare, J. Electrochem. Soc., 165, B804 (2018); https://doi.org/10.1149/2.0121816jes
  27. J.G. Gu, S.P. Cheng, J. Liu and J.D. Gu, J. Polym. Environ., 8, 167 (2000); https://doi.org/10.1023/A:1015293626335
  28. A.J. Bard and L.R. Faulkner, Electrochemical Sensors: Fundamental and Applications, John Wiley & Sons, Inc. edn. 2 (2001).
  29. Y. Abbas, S. Ali, M. Basharat, W. Zou, F. Yang, W. Liu, S. Zhang, Z. Wu, N. Akhtar and D. Wu, ACS Appl. Nano Mater., 3, 11383 (2020); https://doi.org/10.1021/acsanm.0c02466
  30. A. Ajith, N.S.K. Gowthaman, D. Pandiarajan, C. Sugumar and S.A. John, Microchem. J., 199, 110020 (2024); https://doi.org/10.1016/j.microc.2024.110020
  31. E. Iyyappan, S.J. Samuel Justin, P. Wilson and A. Palaniappan, ACS Appl. Nano Mater., 3, 7761 (2020); https://doi.org/10.1021/acsanm.0c01322
  32. H. Zhang and S. Liu, J. Alloys Compd., 842, 155873 (2020); https://doi.org/10.1016/j.jallcom.2020.155873
  33. F. Mazzara, B. Patella, G. Aiello, A. O’Riordan, C. Torino, A. Vilasi and R. Inguanta, Electrochim. Acta, 388, 138652 (2021); https://doi.org/10.1016/j.electacta.2021.138652
  34. X. Xie, D.P. Wang, C. Guo, Y. Liu, Q. Rao, F. Lou, Q. Li, Y. Dong, Q. Li, H.B. Yang and F.X. Hu, Anal. Chem., 93, 4916 (2021); https://doi.org/10.1021/acs.analchem.0c05191
  35. S. Masrat, V. Nagal, M. Khan, A. Ahmad, M.B. Alshammari, S. Alam, U.T. Nakate, B. Lee, P. Mishra, K.S. Bhat and R. Ahmad, ACS Appl. Nano Mater., 6, 16615 (2023); https://doi.org/10.1021/acsanm.3c02794
  36. S. Pramanik, P. Karmakar and D.K. Das, Biointerface Res. Appl. Chem., 13, 134 (2022); https://doi.org/10.33263/BRIAC132.134
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