Copyright (c) 2025 Varsha Manvatkar, R.S. DONGRE
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ultrasonic-Assisted Synthesis, Characterization and Bioactivity of Azomethine based Some Transition Metal(II) Complexes
Corresponding Author(s) : V.D. Manvatkar
Asian Journal of Chemistry,
Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025
Abstract
The present investigation focuses on the synthesis and characterization of coordination compounds of transition metal ions incorporating azomethine ligand, which show a wide range of biological activities. The structure of the ligand and its metal complexes were confirmed by elemental analysis, spectroscopic studies (UV-vis, FTIR and LC-MS ) and magnetic susceptibility measurements. The azomethine ligand was obtained by sonicating 5-bromo-2-hydroxy-3-methoxybenzaldehyde and ethane-1,2-diamine in a 2:1 M ratio. The utilization of sonochemical synthesis techniques for ligand preparation adds an eco-friendly aspect to the process. In particular, the metal-coordinated complexes, which feature azomethine moieties with nitrogen and oxygen atoms for coordination and halogen groups, have attracted significant interest due to their notable bioactive profile. The prepared ligand and its coordinated complexes were evaluated for antimicrobial activities against bacterial microbes (Streptomyces aureus and Pseudomonas aeruginosa) and fungi (Trichoderma viride and Aspergillus niger). The antioxidant activity, as measured by the DPPH method and H2O2 methods, indicates that the coordinated complexes, particularly those of cobalt, nickel and copper, exhibit greater activity than their parent ligand.
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References
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M.J. Niu, Z. Li, G.L. Chang, X.J. Kong, M. Hong and Q. Zhang, PLoS One, 10, e0130922 (2015); https://doi.org/10.1371/journal.pone.0130922
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V.D. Manvatkar, R.Y. Patle, P.H. Meshram and R.S. Dongre, Chem. Pap., 77, 5641 (2023); https://doi.org/10.1007/s11696-023-02889-y
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V.K. Rao, S.S. Reddy, B.S. Krishna, K.R.M. Naidu, C.N. Raju and S.K. Ghosh, Green Chem. Lett. Rev., 3, 217 (2010); https://doi.org/10.1080/17518251003716550
A.M. Abu-Dief and I.M.A. Mohamed, Beni Suef Univ. J. Basic Appl Sci., 4, 119 (2015); https://doi.org/10.1016/j.bjbas.2015.05.004
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G.Q. Zhong and Q. Zhong, Green Chem. Lett. Rev., 7, 236 (2014); https://doi.org/10.1080/17518253.2014.927008
S. S. Manoj Kumar, Atresh Kumar Singh, Vinay K. Singh, Rajesh K. Yadav, Atul P. Singh, Coord. Chem. Rev., 505, 215663 (2024); https://doi.org/10.1016/j.ccr.2024.215663
G. Barone, A. Ruggirello, A. Silvestri, A. Terenzi and V.T. Liveri, J. Inorg. Biochem., 104, 765 (2010); https://doi.org/10.1016/j.jinorgbio.2010.03.012
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J.H. Wang, P.F. Yan, G.M. Li, J.W. Zhang, P. Chen, M. Suda and Y. Einaga, Inorg. Chim. Acta, 363, 3706 (2010); https://doi.org/10.1016/j.ica.2010.05.030
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G.G. Mohamed, M.M. Omar and A.M. Hindy, Turk. J. Chem., 30, 361 (2006).
