Potential of Novel Synthesized Neem Gum and Gelatin Biocomposites based Topical Gel in Effective Wound Healing

Abstract

Wound healing and tissue repair is a complex cascade evolving due to anthropogenic and lifestyle factors. For this purpose, a well-orchestrated wound dressing can help to cover the wound or injury, which protect from surrounding environment and also provide moisture for tissue regeneration. Antimicrobial resistance is one of the major factors in increasing mortality due to wounds. Wound infection is the cause of more than 75% death in post operative infections. The biocomposites of neem gum and gelatin were prepared using crosslinking via pH change method and characterized with Fourier transmission infrared (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. The optimized biocomposite formulation was used to formulate solid dispersions of pure drug clindamycin phosphate. The characterization studies confirmed the absence of drug-biocomposite interactions. The in vitro dissolution studies were carried out to evaluate the effect of amount on biocomposites polymer on the release of clindamycin from the dispersions. The optimized dispersion was incorporated into topical gel and the gel formulation exhibited sustained relese of drug for 24 h. The formulated biocomposites functioned as sustained release polymers and were employed to prolong medication release in wound healing applications.