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Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025

Copyright (c) 2025 Dr Akshatha Nagaraja, Dr Shreya Kanth, Dr Manohara Dhulappa Jalageri

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Design and Synthesis of Quaternized Antimicrobial Polymer against Escherichia coli

https://doi.org/10.14233/ajchem.2025.33244
Akshatha Nagaraja
Department of Chemistry, Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal-576104, India
https://orcid.org/0000-0003-4749-1479
Shreya Kanth
Department of Chemistry, NMAM Institute of Technology, NITTE (Deemed to be University), Nitte-574110, India
https://orcid.org/0000-0002-8340-8874
Manohara Dhulappa Jalageri
Department of Chemistry, Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal-576104, India
https://orcid.org/0000-0002-3054-9761

Corresponding Author(s) : Manohara Dhulappa Jalageri

jd.manohar@manipal.edu

Asian Journal of Chemistry, Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025

Abstract

New strategies and approaches are required due to the rising levels of antibiotic resistance, which are frequently brought on by long-term misuse or overuse of conventional antimicrobial medications. Due to their minimal potential to produce drug-resistant bacteria, effective antimicrobial polymers have been garnering more attention. The incorporation of quaternary ammonium groups into polymers is among the most beneficial methods for fabricating biomaterials with antimicrobial properties. This study presents the synthesis pathway on developing quaternized jeffamine polymer (QJP) with efficient antimicrobial property. The QJP was prepared by post polymerization modification of Jeffamine ED2003 and the structural integrity of the QJP was investigated by NMR and thermal properties. The synthesized QJP exhibited activity against E. coli and kill time assay revealed the synthesized polymer has a bacteriostatic effect.

Keywords

Escherichia coli Minimum inhibitory concentration Time kill assay
Nagaraja, A., Kanth, S., & Jalageri, M. D. (2025). Design and Synthesis of Quaternized Antimicrobial Polymer against Escherichia coli. Asian Journal of Chemistry, 37(3), 633–640. https://doi.org/10.14233/ajchem.2025.33244
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