Synthesis and Biological Evaluation of New Chalcone based Thiazole Derivatives: Antimicrobial, Antifungal Activity, ADME and Molecular Docking Studies

D. Geetha; Y.B. Basavaraju; K. Roopa

doi:10.14233/ajchem.2025.33226

Issue

Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025

Issue Published : 28 February 2025

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Biological Evaluation of New Chalcone based Thiazole Derivatives: Antimicrobial, Antifungal Activity, ADME and Molecular Docking Studies

https://doi.org/10.14233/ajchem.2025.33226

D. Geetha

Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India; Department of Chemistry, Maharani’s Science College for Women (Autonomous), Mysore-570005, India

https://orcid.org/0009-0000-6818-8706

Y.B. Basavaraju

Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India

https://orcid.org/0009-0000-0053-510X

K. Roopa

Department of Biochemistry, Maharani’s Science College for Women (Autonomous), Mysore-570005, India

https://orcid.org/0009-0005-8709-9828

Corresponding Author(s) : Y.B. Basavaraju

ybbuom@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 3 (2025): Vol 37 Issue 3, 2025
Article Published : 28 February 2025

Abstract

The Claisen-Schmidt condensation reaction of 2-acetyl thiophene with heterocyclic carboxaldehyde or substituted benzaldehyde in the presence of alkaline medium was used to synthesize novel thiophene chalcones. Several chalcone heterocycle hybrids appear to have more activity than the standards. These chalcones can be hydroaminated to provide good yields of amino thiazole derivatives. The newly synthesized compounds were characterized with spectroscopic techniques including FT-IR, ¹H NMR, ¹³C NMR and HRMS. In addition to a seed germination inhibition test and an evaluation of the synthesized compounds in vitro antibacterial activity against a variety of bacteria and fungi, the synthesized aminothiazole derivatives underwent molecular docking and in silico ADMET studies.

Keywords

Chalcones Thiazoles Antibacterial activity Antifungal activity Seed germination

Geetha, D., Basavaraju, Y., & Roopa, K. (2025). Synthesis and Biological Evaluation of New Chalcone based Thiazole Derivatives: Antimicrobial, Antifungal Activity, ADME and Molecular Docking Studies. Asian Journal of Chemistry, 37(3), 593–600. https://doi.org/10.14233/ajchem.2025.33226

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D.M. Wiles and T. Suprunchuk, J. Med. Chem., 14, 252 (1971); https://doi.org/10.1021/jm00285a023

H.K. Keerthy, M. Garg, C.D. Mohan, V. Madan, D. Kanojia, R. Shobith, S. Nanjundaswamy, D.J. Mason, A. Bender, K.S. Basappa, K.S. Rangappa and H.P. Koeffler, PLoS One, 9, 107118 (2014); https://doi.org/10.1371/journal.pone.0107118

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B.A. Ayinde, E.K.I. Omogbai and E.O. Ikpefan, Niger. J. Pharm. Sci., 10, 16 (2011).

N.I.M. Nayak and P. Lakshmi, J. Pharmacol. Pharmacother., 5, 56 (2014); https://doi.org/10.4103/0976-500X.124426

Author biographies is not available.