Copyright (c) 2015 AJC
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A New Isocoumarin from Fermentation Products of Endophytic Fungus of Aspergillus versicolor
Corresponding Author(s) : Hai-Ying Yang
Asian Journal of Chemistry,
Vol. 27 No. 10 (2015): Vol 27 Issue 10
Abstract
A new isocoumarin, versicoumarin D, was isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Its structure was elucidated by spectroscopic methods, including extensive 1D NMR and 2D NMR techniques. Compound 1 was also tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed high cytotoxicity against A549 and MCF7 cell with IC50 values of 5.8 and 8.0 μM, respectively.
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References
Y. Liang, W. Zhao, J.P. Xu and J.D. Miller, Int. Biodeter. Biodegrad., 65, 217 (2011); doi:10.1016/j.ibiod.2010.11.005.
J.M. Restrepo-Florez, A. Bassi and M.R. Thompson, Int. Biodeter. Biodegrad., 88, 83 (2014); doi:10.1016/j.ibiod.2013.12.014.
R.X. Li, S.X. Chen, S.B. Niu, L.D. Guo, J. Yin and Y.S. Che, Fitoterapia, 96, 88 (2014); doi:10.1016/j.fitote.2014.04.013.
U.W. Hawas, A.A. El-Beih and A.M. El-Halawany, Arch. Pharm. Res., 35, 1749 (2012); doi:10.1007/s12272-012-1006-x.
M. Figueroa, H. Raja, J.O. Falkinham III, A.F. Adcock, D.J. Kroll, M.C. Wani, C.J. Pearce and N.H. Oberlies, J. Nat. Prod., 76, 1007 (2013); doi:10.1021/np3008842.
J. Qi, C.L. Shao, Z.Y. Li, L.S. Gan, X.M. Fu, W.T. Bian, H.Y. Zhao and C.Y. Wang, J. Nat. Prod., 76, 571 (2013); doi:10.1021/np3007556.
H.L. Jiang, X.H. Luo, X.Z. Wang, J.L. Yang, X.J. Yao, P. Crews, F.A. Valeriote and Q.X. Wu, Fitoterapia, 83, 1275 (2012); doi:10.1016/j.fitote.2012.06.005.
S.L. Luo, X.J. Huang, Y. Wang, R.W. Jiang, L. Wang, L.L. Bai, Q.L. Peng, C.L. Song, D.M. Zhang and W.C. Ye, Fitoterapia, 95, 115 (2014); doi:10.1016/j.fitote.2014.03.004.
J. Kornsakulkarn, C. Thongpanchang, S. Lapanun and K. Srichomthong, J. Nat. Prod., 72, 1341 (2009); doi:10.1021/np900082h.
K. Tianpanich, S. Prachya, S. Wiyakrutta, C. Mahidol, S. Ruchirawat and P. Kittakoop, J. Nat. Prod., 74, 79 (2011); doi:10.1021/np1003752.
L.C. Di Stasi, D. Camuesco, A. Nieto, W. Vilegas, A. Zarzuelo and J. Galvez, Planta Med., 70, 315 (2004); doi:10.1055/s-2004-818942.
Q.-F. Hu, B. Zhou, Y.-Q. Ye, Z.-Y. Jiang, X.-Z. Huang, Y.-K. Li, G. Du, G.-Y. Yang and X.-M. Gao, J. Nat. Prod., 76, 1854 (2013); doi:10.1021/np400379u.
M. Shibano, H. Naito, M. Taniguchi, N.H. Wang and K. Baba, Chem. Pharm. Bull. (Tokyo), 54, 717 (2006); doi:10.1248/cpb.54.717.