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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Nawaj Ali beg chemistry, Dr. Maqdoom Farooqui

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Facile Synthesis of New Substituted 4-Thiazolidinones Conjugates containing Quinoline-Sulfamethoxazole Motifs and their Bioevaluation

https://doi.org/10.14233/ajchem.2025.33177
Nawaj Ali Beg
Department of Chemistry, Maulana Azad Post Graduate & Research Centre, Aurangabad-431001, India
https://orcid.org/0009-0002-3489-3372
Maqdoom Farooqui
Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad-431001, India
https://orcid.org/0000-0003-2749-4795

Corresponding Author(s) : Nawaj Ali Beg

nawaja91@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

Difunctional Brönsted acidic ionic liquid [DBN][HSO4] mediated synthesis of quinoline-sulfamethoxazole blended 4-thiazolidinones derivatives (7a-l) by reacting 4-amino-N-(5-methylisoxazol-3-yl) benzenesulfonamide (4), 2-chloro-3-formyl quinoline (5a-l) and mercapto acetic acid (6) in promising yields at 80 ºC. All the newly synthesized quinoline-sulfamethaoxazole incorporated 4-thiazolidinones derivatives were explored for their in vitro antifungal and antioxidant activity. The novel compounds, 4-thiazolidinones hybrids were evaluated against various fungal strains and compounds 7g, 7h, 7i, 7j and 7k displays promising antifungal activity. Furthermore, all the synthesized 4-thiazolidinones conjugates were evaluated for antioxidant activity and almost all derivatives (7b-l) exhibit excellent radical activity. Using [DBN][HSO4] protocol providing economical as well as environmental advantages and its applicable for divergent functional groups.

Keywords

Ionic liquid 4-Thiazolidinones Quinoline Sulfamethaoxazole Antifungal activity
Beg, N. A., & Farooqui, M. (2025). Facile Synthesis of New Substituted 4-Thiazolidinones Conjugates containing Quinoline-Sulfamethoxazole Motifs and their Bioevaluation. Asian Journal of Chemistry, 37(2), 455–464. https://doi.org/10.14233/ajchem.2025.33177
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