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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Suhaila, Nasheetha Rahman , Dr Kavitha M Manneledam

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Enhanced Antimicrobial Activity of PVP-ALG/ZnO Nanocomposite Films with Controlled Drug Release and UV Blocking Properties

https://doi.org/10.14233/ajchem.2025.33109
Suhaila Thattaril
Post Graduate and Research Department of Chemistry, Zamorins Guruvayurappan College (Affiliated to University of Calicut), Kozhikode-673014, India; Department of Chemistry, Government College, Kodanchery-673580, India
https://orcid.org/0009-0000-7345-6496
Nasheetha Rahman Thythottathil
Post Graduate and Research Department of Chemistry, Zamorins Guruvayurappan College (Affiliated to University of Calicut), Kozhikode-673014, India
https://orcid.org/0009-0001-9801-4624
Kavitha Manniledam
Post Graduate and Research Department of Chemistry, Zamorins Guruvayurappan College (Affiliated to University of Calicut), Kozhikode-673014, India
https://orcid.org/0009-0003-4505-3325

Corresponding Author(s) : Kavitha Manniledam

kavitham@zgcollege.ac.in

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

A novel PVP-ALG/ZnO hydrogel nanocomposite film was synthesized using a solution casting method. By incorporating ZnO nanoparticles into a polyvinylpyrrolidone (PVP) and sodium alginate (ALG) hydrogel, the nanocomposite film demonstrated enhanced antimicrobial, mechanical and UV-blocking properties. Characterization techniques, including XRD, SEM, TEM and UTM, revealed an optimal tensile strength at a 0.0075 g ZnO composition. The composite exhibited superior swelling behaviour compared to pure PVP-ALG hydrogel in distilled water and buffer solution of pH 6.8. Drug-loading studies with cephalexin showed slower, sustained release under intestinal pH (6.8), attributed to ZnO-induced interactions. Antimicrobial analysis confirmed enhanced effectiveness and UV-blocking tests highlighted a high sun protection factor (SPF) of 7.9 for the nanocomposite film. The results highlighted the potential of the PVP-ALG/ZnO hydrogel as an excellent option for use in biomedical and pharmaceutical fields, especially for sustained drug delivery and protective applications.

Keywords

PVP-ALG/ZnO nanocomposite Swelling study Antimicrobial Drug delivery UV blocking ability
Thattaril, S., Thythottathil, N. R., & Manniledam, K. (2025). Enhanced Antimicrobial Activity of PVP-ALG/ZnO Nanocomposite Films with Controlled Drug Release and UV Blocking Properties. Asian Journal of Chemistry, 37(2), 392–400. https://doi.org/10.14233/ajchem.2025.33109
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