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Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

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Spectral Characterization, Thermal and Antimicrobial Studies of Some Divalent Metal Chelates of 7-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol

https://doi.org/10.14233/ajchem.2020.22746
Asma A. Alothman
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
Munirah D. Albaqami
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
Razan A. Alshgari
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia

Corresponding Author(s) : Asma A. Alothman

aaalothman@ksu.edu.sa

Asian Journal of Chemistry, Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

Abstract

A series of Cu(II), Ni(II) and Co(II) azo chelates (AZC1-AZC3) of 7-((3-phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol have been designed and obtained. Thermal measurements, molar conductance, magnetic moment, elemental analyses, spectral (IR, UV-Vis, 1H and 13C NMR, ESR, mass) were used to characterize insulated solid complexes. The metal complexes were assumed to be non-electrolytic by molar conductance values. Thermal properties and decomposition kinetics of the metal chelates are investigated using Coats-Redfern method. The kinetic parameters like activation energy (E*), pre-exponential factor (A) and entropy of activation (ΔS*) were quantified. Results of spectral studies of mass and TGA data confirmed the octahedral geometry for all chelates. Finally, the synthesized metal-complexes were tested for their in vitro antimicrobial efficacy.

Keywords

Azo dye chelates DFT Antimicrobial efficacy
A. Alothman, A., D. Albaqami, M., & A. Alshgari, R. (2020). Spectral Characterization, Thermal and Antimicrobial Studies of Some Divalent Metal Chelates of 7-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol. Asian Journal of Chemistry, 32(9), 2356–2364. https://doi.org/10.14233/ajchem.2020.22746
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