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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Synthesis, Characterization and Bioactivity Study of Bidentate NS Schiff Base of S-Benzyl Dithiocarbazate and its Zn(II) and Pd(II) Complexes

https://doi.org/10.14233/ajchem.2020.21870
Md. Hasibul Islam
Department of Chemistry, Rajshahi University of Engineering & Technology, Rajshahi-6204, Bangladesh
Md. Chanmiya Sheikh
Department of Environmental Applied Chemistry, Faculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan
Ryuta Miyatake
Water Quality Management Center, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan
Ronok Zahan
Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
Md. Al-Amin-Al-Azadul Islam
Department of Chemistry, Rajshahi University of Engineering & Technology, Rajshahi-6204, Bangladesh
https://orcid.org/0000-0001-5204-7802

Corresponding Author(s) : Md. Hasibul Islam

mhislamchem.bsfic@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

The bis-chelated four coordinate complexes (ML2, L = deprotonated ligand) of Zn(II) and Pd(II) ions were synthesized, derived from a new bidentate NS Schiff base called S-benzyl-β-N-(4- hydroxy-3-nitrophenyl)methylene dithiocarbazate (HL) which is the condensation product of S-benzyl dithiocarbazate (SBDTC) with 4-hydroxy-3-nitrobenzaldehyde. The synthesized ligand  and complexes were characterized using conventional techniques like NMR, UV-visible, IR, mass spectroscopic techniques, magnetic susceptibility measurement and molar conductance. A  single crystal X-ray crystallography data approved the proposed crystal structure of the ligand. Both in solid and solution phase, the ligand continues to exist in its thione tautomeric form.  The chelates were formed by the reaction of ligand with the metal ions through the ligand azomethine nitrogen atom and the deprotonated thiolate sulfur anion. Magnetic susceptibility  and electronic spectroscopic data suggested to have a tetrahedral geometry for ZnL2 complex whereas a square planar structure for PdL2 complex. The analgesic and anti-inflammatory  bioactivity were assayed on both the ligand and its complexes by tail flick and carrageenan induced paw edema test. The ligand at the dose of 10 mg/kg, produced a significant (***p <  0.001) increase in pain threshold in tail flick methods when compared to control but in case of complexes, it showed moderate activity. At the same dose, the ligand and complexes significantly (***p < 0.001) reduced paw edema when compared to the control. Altogether, these results suggest that ligand and its complexes could be used as a potent anti- inflammatory agent. 

Keywords

Schiff base S-Benzyl Dithiocarbazate Metal(II) complexes Analgesic activity Antiinflammatory activity
Islam, M. H., Sheikh, M. C. ., Miyatake, R. ., Zahan, R. ., & Islam, M. A.-A.-A.-A. . (2020). Synthesis, Characterization and Bioactivity Study of Bidentate NS Schiff Base of S-Benzyl Dithiocarbazate and its Zn(II) and Pd(II) Complexes. Asian Journal of Chemistry, 32(8), 2091–2098. https://doi.org/10.14233/ajchem.2020.21870
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