Issue

Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Resveratrol Derivatives as Anticancer Agents

https://doi.org/10.14233/ajchem.2020.22680
Vema Venkata Naresh
1 GVK Biosciences Private Limited, Nacharam, IDA Mallapur, Hyderabad-500076, India 2 Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
Y. Bharathi Kumari
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
Mussulla Sridhar
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
Addada Ramakrishnam Raju
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
A. Srinivasa Rao
GVK Biosciences Private Limited, Nacharam, IDA Mallapur, Hyderabad-500076, India

Corresponding Author(s) : Vema Venkata Naresh

naresh.vema@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

A novel target compounds (9a-j) were design and synthesized and characterized by 1H & 13C NMR, ESI-MS spectral analysis. Further, these were tested for their anticancer activity against three human cancer cell lines such as MCF-7, MDA MB-231 (breast), A549 (Lung) and adriamycin was used as positive control. Among ten compounds, two compounds like 9b and 9j were showed a significant anticancer activity compared to control drug.

Keywords

1,3,4-Oxadiazoles Resveratrol Combretastatin A-4 Zibotentan Anticancer activity
Naresh, V. V. ., Kumari, Y. B. ., Sridhar, M., Raju, A. R. ., & Rao, A. S. . (2020). Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Resveratrol Derivatives as Anticancer Agents. Asian Journal of Chemistry, 32(8), 1967–1971. https://doi.org/10.14233/ajchem.2020.22680
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. J.A. Baur and D.A. Sinclair, Nat. Rev. Drug Discov., 5, 493 (2006); https://doi.org/10.1038/nrd2060
  2. B.B. Aggarwall and S. Shishodia, Resveratrol in Health and Disease; Taylor & Francis: Boca Raton, FL, USA (2006).
  3. Y. Schneider, F. Vincent, B. Duranton, L. Badolo, F. Gosse, C. Bergmann, N. Seiler and F. Raul, Cancer Lett., 158, 85 (2000); https://doi.org/10.1016/S0304-3835(00)00511-5
  4. F. Uenobe, S. Nakamura and M. Miyazawa, Mutat. Res., 373, 197 (1997); https://doi.org/10.1016/S0027-5107(96)00191-1
  5. G.B. Mahady, Oxidat. Stress Dis., 20, 465 (2006).
  6. L.L. Creasy and M.J. Coffee, J. Am. Soc. Hortic. Sci., 113, 230 (1988).
  7. N. Kawada, S. Seki, M. Inoue and T. Kuroki, Hepatology, 27, 1265 (1998); https://doi.org/10.1002/hep.510270512
  8. J.J. Docherty, M.M.H. Fu, B.S. Stiffler, R.J. Limperos, C.M. Pokabla and A.L. DeLucia, Antiviral Res., 43, 145 (1999); https://doi.org/10.1016/S0166-3542(99)00042-X
  9. B.D. Gehm, J.M. McAndrews, P.Y. Chien and J.L. Jameson, Proc. Natl. Acad. Sci. USA, 94, 14138 (1997); https://doi.org/10.1073/pnas.94.25.14138
  10. M. Virgili and A. Contestabile, Neurosci. Lett., 281, 123 (2000); https://doi.org/10.1016/S0304-3940(00)00820-X
  11. Z.R. Wang, Y.Z. Huang, J.G. Zou, K.J. Cao, Y.N. Xu and J.M. Wu, Int. J. Mol. Med., 9, 77 (2002);https://doi.org/10.3892/ijmm.9.1.77
  12. P. Kopp, Eur. J. Endocrinol., 138, 619 (1998); https://doi.org/10.1530/eje.0.1380619
  13. X.P. Lei, B. Liu and N. Zhu, Zhongguo Xin Yao Zazhi, 9, 540 (2000).
  14. G.R. Pettit, S.B. Singh, M.L. Niven, E. Hamel and J.M. Schmidt, J. Nat. Prod., 50, 119 (1987); https://doi.org/10.1021/np50049a016
  15. G.R. Pettit, G.M. Cragg and S.B. Singh, J. Nat. Prod., 50, 386 (1987); https://doi.org/10.1021/np50051a008
  16. G.M. Tozer, C. Kanthou, C.S. Parkins and S.A. Hill, Int. J. Exp. Pathol., 83, 21 (2002); https://doi.org/10.1046/j.1365-2613.2002.00211.x
  17. S. Bondock, S. Adel, H.A. Etman and F.A. Badria, Eur. J. Med. Chem., 48, 192 (2012); https://doi.org/10.1016/j.ejmech.2011.12.013
  18. N.N. Farshori, M.R. Banday, A. Ahmad, A.U. Khan and A. Rauf, Bioorg. Med. Chem. Lett., 20, 1933 (2010); https://doi.org/10.1016/j.bmcl.2010.01.126
  19. A.A. El-Emam, O.A. Al-Deeb, M. Al-Omar and J. Lehmann, Bioorg. Med. Chem., 12, 5107 (2004); https://doi.org/10.1016/j.bmc.2004.07.033
  20. S.G. Kucukguzel, E.E. Oruc, S. Rollas, F. Sahin and A. Ozbek, Eur. J. Med. Chem., 37, 197 (2002); https://doi.org/10.1016/S0223-5234(01)01326-5
  21. Y.H. Li, H.J. Zhu, K. Chen, R. Liu, A. Khallaf, X.N. Zhang and J.P. Ni, Org. Biomol. Chem., 11, 3979 (2013); https://doi.org/10.1039/c3ob40345a
  22. Z.N. Cui, Y.X. Shi, L. Zhang, Y. Ling, B.J. Li, Y. Nishida and X.L. Yang, J. Agric. Food Chem., 60, 11649 (2012); https://doi.org/10.1021/jf303807a
  23. M.Y. Wani, A. Ahmad, R.A. Shiekh, K.J. Al-Ghamdi and A.J.F.N. Sobral, Bioorg. Med. Chem., 23, 4172 (2015); https://doi.org/10.1016/j.bmc.2015.06.053
  24. B. Jayashankar, K.M. Lokanathrai, N. Baskaran and H.S. Sathish, Eur. J. Med. Chem., 44, 3898 (2009); https://doi.org/10.1016/j.ejmech.2009.04.006
  25. N. Ingale, V. Maddi, M. Palkar, P. Ronad, A.H.M. Vishwanathswamy, S. Mamledesai and D. Satyanarayana, Med. Chem. Res., 21, 16 (2012); https://doi.org/10.1007/s00044-010-9494-z
  26. D. Sriram, D. Banerjee and P. Yogeeswari, J. Enzyme Inhib. Med. Chem., 24, 1 (2009); https://doi.org/10.1080/14756360701404159
  27. M.T.H. Khan, M.I. Choudhary, K.M. Khan, M. Rani and Atta-ur-Rahman, Bioorg. Med. Chem., 13, 3385 (2005); https://doi.org/10.1016/j.bmc.2005.03.012
  28. A. Almasirad, S.A. Tabatabai, M. Faizi, A. Kebriaeezadeh, N. Mehrabi, A. Dalvandi and A. Shafiee, Bioorg. Med. Chem. Lett., 14, 6057 (2004); https://doi.org/10.1016/j.bmcl.2004.09.072
  29. Y. Li, Y. Luo, Y. Hu, D.-D. Zhu, S. Zhang, Z.-J. Liu, H.-B. Gong and H.-L. Zhu, Bioorg. Med. Chem., 20, 4316 (2012); https://doi.org/10.1016/j.bmc.2012.05.050
  30. K. Laskar, P. Alam, R.H. Khan and A. Rauf, Eur. J. Med. Chem., 122, 72 (2016);https://doi.org/10.1016/j.ejmech.2016.06.012
  31. A. Vaidya, S. Jain, P. Jain, P. Jain, N. Tiwari, R. Jain, R. Jain, A.K. Jain and R.K. Agrawal, Mini Rev. Med. Chem., 16, 825 (2016); https://doi.org/10.2174/1389557516666160211120835
  32. N.D. James and J.W. Growcott, Drugs Future, 34, 624 (2009);https://doi.org/10.1358/dof.2009.34.8.1400202
  33. M. Roberti, D. Pizzirani, D. Simoni, R. Rondanin, R. Baruchello, C. Bonora, F. Buscemi, S. Grimaudo and M. Tolomeo, J. Med. Chem., 46, 3546 (2003); https://doi.org/10.1021/jm030785u
  34. N.U.A. Mohsin and M. Irfan, J. Chil. Chem. Soc., 63, 4135 (2018); https://doi.org/10.4067/s0717-97072018000304135
  35. P.N. Reddy, P. Padmaja, B.R. Reddy, G. Rambabu and M.P. Kumar, Med. Chem. Res., 25, 2093 (2016); https://doi.org/10.1007/s00044-016-1676-x
  36. L. Li, S. Jiang, X. Li, Y. Liu, J. Su and J. Chen, Eur. J. Med. Chem., 151, 482 (2018);https://doi.org/10.1016/j.ejmech.2018.04.011
Read More
Author biographies is not available.
Statistic
Read Counter : 0 Download : 7