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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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DNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes

https://doi.org/10.14233/ajchem.2020.22700
Murugan Selvamariammal
Department of Chemistry, Sri S. Ramasamy Naidu Memorial College, Sattur-626203, India
https://orcid.org/0000-0002-1129-2227
Maruthappan Malarvizhi
https://orcid.org/0000-0002-9753-0707

Corresponding Author(s) : Murugan Selvamariammal

selvamariammal23384@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

Some novel series of 5-chloro isatin and 4-aminoantipyrine based Schiff bases with transition metal(II) complexes of (Cu, Co, Ni and Zn) have been prepared and characterized by physical,  analytical and spectral data. The synthesized ligand behaves as a neutral tridentate is confirmed by spectral techniques. During the complexation, the stoichiometry ratio 1:2 (metal:ligand) is  followed and an octahedral arrangement is adopted by all the metal complexes. The calf-thymus DNA interacts with complexes via an intercalative mode is studied by electronic absorption  titration. Moreover, all these synthesized metal(II) complexes were tested against a set of bacterial and fungal strains reveals that complexes exhibit better activity than free ligand.

Keywords

5-Chloro isatin 4-Aminoantipyrine Antimicrobial studies DNA binding
Selvamariammal, M. ., & Malarvizhi, M. . (2020). DNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes. Asian Journal of Chemistry, 32(8), 1903–1908. https://doi.org/10.14233/ajchem.2020.22700
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