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Vol. 32 No. 6 (2020): Vol 32 Issue 6

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Synthesis, Characterization and Molecular Docking of 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

https://doi.org/10.14233/ajchem.2020.22594
Panneerselvam Kalaivani
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India
Jayaraman Arikrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India*Corresponding author: E-mail: mgkrishnan61@gmail.com
Mannuthusamy Gopalakrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India

Corresponding Author(s) : Mannuthusamy Gopalakrishnan

mgkrishnan61@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 6 (2020): Vol 32 Issue 6

Abstract

In this study, a new series of (E)-N-(4-(3-(3,5-dialkylphenyl)acryloyl)phenyl)-2-(1H-1,2,4-triazol-1-yl)acetamide (32-41) was synthesized, characterized by FT-IR, 1H NMR, 13C NMR and Mass spectral analysis and evaluated for their in vitro antibacterial and antifungal activities. The docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of 1T9U protein. The zone of inhibition concentration was tested for the synthesized compounds against five bacterial and three fungal strains. Compounds 34 and 37 have good antibacterial activity. Compounds 3, 4 and 6 shows moderate inhibition against the antifungal activity.

Keywords

Molecular docking 1T9U Protein Antibacterial activity Antifungal activity. 1,2,4-Triazole
Kalaivani, P., Arikrishnan, J., & Gopalakrishnan, M. (2020). Synthesis, Characterization and Molecular Docking of 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents. Asian Journal of Chemistry, 32(6), 1437–1442. https://doi.org/10.14233/ajchem.2020.22594
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