Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs

Ch. Jithendra; G. Saravanan; V. Alagarsamy; T. Panneerselvam; K. Selvaraj; P. Parasuraman

doi:10.14233/ajchem.2020.22596

Issue

Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Issue Published : February 25, 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs

https://doi.org/10.14233/ajchem.2020.22596

Ch. Jithendra

Department of Pharmaceutical Sciences, Vignan's Foundation for Science, Technology & Research, Guntur-522213, India

G. Saravanan

Department of Pharmaceutical Chemistry, M.N.R. College of Pharmacy, Fasalwadi, Sangareddy-502294, India

V. Alagarsamy

Department of Pharmaceutical Chemistry, M.N.R. College of Pharmacy, Fasalwadi, Sangareddy-502294, India

T. Panneerselvam

Department of Pharmaceutical Chemistry, Saraswathi College of Pharmacy, Pilkhuwa, Hapur-245304, India

https://orcid.org/0000-0002-8197-4688

K. Selvaraj

Sir C.V. Raman-KS Krishnan International Research Center, Kalasalingam Academy of Research and Education, Krishnankoil-626126, India

https://orcid.org/0000-0002-6741-5118

P. Parasuraman

Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, M.S.R. Nagar, Bengaluru-560054, India

Corresponding Author(s) : G. Saravanan

sarachem1981@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020
Article Published : February 25, 2020

Abstract

A sequence of new isoxazole substituted Schiff base and Mannich base of 5-nitroisatin are synthesized by a multi-step synthesis from 5-nitroisatin. Whole synthesized analogs were characterized using IR, NMR, Mass spectroscopy and microanalyses. All the Schiff and Mannich bases were tested for their antimicrobial potencies against some human pathogenic microorganism using agar well diffusion technique. The relationship between the biological activity and the functional group variation of the Schiff and Mannich bases were analyzed. Standard ciprofloxacin and ketoconazole were used to compare the antimicrobial activities of novel isatin coupled isoxazole derivatives.

Keywords

Isatin Isoxazole 5-Nitroisatin Microbial activity

Jithendra, C., Saravanan, G., Alagarsamy, V., Panneerselvam, T., Selvaraj, K., & Parasuraman, P. (2020). Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs. Asian Journal of Chemistry, 32(4), 970–974. https://doi.org/10.14233/ajchem.2020.22596

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References

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References

M. Subramanyam, R. Sreenivasulu, R. Gundla, M.V.B. Rao and K.P. Rao, Lett. Drug Des. Discov., 15, 1299 (2018); https://doi.org/10.2174/1570180815666180219165119

S. Boddupally, P. Jyothi, M.V.B. Rao and K.P. Rao, J. Heterocycl. Chem., 56, 73 (2019); https://doi.org/10.1002/jhet.3373

B. Srinivas, J. Suryachandram, Y.K. Devi and K.P. Rao, J. Heterocycl. Chem., 54, 3730 (2017); https://doi.org/10.1002/jhet.2960

F. Qadri, A.M. Svennerholm, A.S.G. Faruque and R.B. Sack, Clin. Microbiol. Rev., 18, 465 (2005); https://doi.org/10.1128/CMR.18.3.465-483.2005

R.A. Devasia, T.F. Jones, J. Ward, L. Stafford, H. Hardin, C. Bopp, M. Beatty, E. Mintz and W. Schaffner, Am. J. Med., 119, 168 (2006); https://doi.org/10.1016/j.amjmed.2005.07.063

S.E. Beekmann, K.P. Heilmann, S.S. Richter, J. Garcia deLomas and G.V. Doern, Int. J. Antimicrob. Agents, 25, 148 (2005); https://doi.org/10.1016/j.ijantimicag.2004.09.016

B. Spellberg, R. Guidos, D. Gilbert, J. Bradley, H. Boucher, W.T. Scheld, J. Bartlett and J. Edwards, Clin. Infect. Dis., 46, 155 (2008); https://doi.org/10.1086/524891

K. Suman, K.P. Rao, M.V.B. Rao and M. Pal, Mini Rev. Med. Chem., 18, 1064 (2018); https://doi.org/10.2174/1389557518666180117093706

Z.-M. Lian, J. Sun and H.-L. Zhu, J. Mol. Struct., 1117, 8 (2016); https://doi.org/10.1016/j.molstruc.2016.03.036

V. Ugale, H. Patel, B. Patel and S. Bari, Arabian J. Chem., 10(S1), s389 (2017); https://doi.org/10.1016/j.arabjc.2012.09.011

R. Wang, X. Yin, Y. Zhang and W. Yan, Eur. J. Med. Chem., 156, 580 (2018); https://doi.org/10.1016/j.ejmech.2018.07.025

M.A. Ganim, M.C. Baloglu, A. Aygun, Y.C. Altunoglu, H.S. Sayiner, F. Kandemirli and F. Sen, Int. J. Biol. Macromol., 122, 1271 (2019); https://doi.org/10.1016/j.ijbiomac.2018.09.084

M.F. Abo-Ashour, W.M. Eldehna, R.F. George, M.M. Abdel-Aziz and S.M. Abou-Seri, Eur. J. Med. Chem., 160, 49 (2018); https://doi.org/10.1016/j.ejmech.2018.10.008

W.S. Hamama, M.E. Ibrahim and H.H. Zoorob, J. Heterocycl. Chem., 54, 341 (2017); https://doi.org/10.1002/jhet.2589

S. Anjani, P. Kirti and P. Rajinikant, Indian J. Chem., 52B, 671 (2013).

C.H. Gill, P.V. Badadhe, N.M. Chavan, P.G. Mandhane, R.S. Joshi and D.R. Nagargoje, Indian J. Chem., 50B, 879 (2011).

P.M. Hawkey and D.A. Lewis, Medical Bacteriology-A Practical Approach, Oxford University Press: United Kingdom, pp. 181-194 (1994).

S.H. Gillespie, Medical Microbiology-Illustrated, ButterworthHeinemann: United Kingdom (1994).

Issue

Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs

Corresponding Author(s) : G. Saravanan

Abstract

Keywords

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