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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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Synthesis, Anti-inflammatory Activity and in silico Studies of Some Novel Morpholine Based Carboxamides

https://doi.org/10.14233/ajchem.2020.22488
Premanand M. Honavar
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College of Arts, Science, Commerce, BBA and P.G. Centre, Honavar-581334, India; Department of Studies and Research in Organic Chemistry, Tumkur University, Tumkur-572103, India
Vasantha Kumar
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India
Nikhil P.
Department of Studies and Research in Chemistry, Mangalore University, Mangalagangotri-574199, India
Naveen Kumar
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India
S. Sreenivasa
Department of Studies and Research in Organic Chemistry, Tumkur University, Tumkur-572103, India
Vishwanatha P.
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India
Boja Poojary
Department of Studies and Research in Chemistry, Mangalore University, Mangalagangotri-574199, India
B. Shivarama Holla
Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India

Corresponding Author(s) : B. Shivarama Holla

hollabs@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

Two series of carboxamides were synthesized from 3-fluoro-4-morpholinoaniline and different substituted aromatic/heterocyclic carboxylic acids. All the compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized amide derivatives were screened for anti-inflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, compound 6e was found to be highly potent. Molecular docking interaction of active compounds revealed that effective binding was observed in the pocket of COX-I and COX-II proteins.

Keywords

Carboxamides Morpholinyl Pyridine Antiinflammatory activity Docking studies
Honavar, P. M., Kumar, V., P., N., Kumar, N., Sreenivasa, S., P., V., … Holla, B. S. (2020). Synthesis, Anti-inflammatory Activity and in silico Studies of Some Novel Morpholine Based Carboxamides. Asian Journal of Chemistry, 32(4), 901–906. https://doi.org/10.14233/ajchem.2020.22488
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