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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties

https://doi.org/10.14233/ajchem.2020.22490
M. Idrees
Department of Chemistry, Institute of Science, Nagpur-440001, India
Y.G. Bodkhe
Department of Chemistry, Government Science College, Gadchiroli-442605, India
N.J. Siddiqui
Department of Chemistry, Institute of Science, Nagpur-440001, India
S.S. Kola
Department of Chemistry, Government Science College, Gadchiroli-442605, India

Corresponding Author(s) : M. Idrees

idreesshaikh.2009@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3-yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence of catalytic amount of acetic acid gave intermediate compounds (3a-f). The structures of newly synthesized compounds have been substantiated through elemental analysis and spectral studies viz. 1H NMR, 13C NMR, IR and mass spectra. All the synthesized compounds were screened for their in vitro antibacterial activity against pathogenic bacteria such as S. aureus and E. coli at different concentrations.

Keywords

Azetidinones p-Tolyloxy Quinoline carbaldehyde Pyrazole Carbohydrazides
Idrees, M., Bodkhe, Y., Siddiqui, N., & Kola, S. (2020). Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties. Asian Journal of Chemistry, 32(4), 896–900. https://doi.org/10.14233/ajchem.2020.22490
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