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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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SnCl2 Catalyzed Direct Synthesis of Pyrroles under Aqueous Conditions

https://doi.org/10.14233/ajchem.2020.22454
D. Tejeswararao
Department of Chemistry, GMR Institute of Technology, Rajam-532127, India
B. Srikanth
Department of Chemistry, Indian Institute of Chemical Technology, Hyderabad-500007, India

Corresponding Author(s) : D. Tejeswararao

tejeswararao.d@gmrit.edu.in

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

Synthetic substituted pyrroles are related with interesting biological activities, yet they remain inadequately explored within drug discovery. Late years have seen a growing interest in synthetic approaches that can provide access to structurally novel pyrroles so that the biological usefulness of this compound class can be more fully investigated. Herein, an efficient and versatile practical protocol for the pyrroles using stannous(II) chloride dihydrate as catalyst is described under aqueous conditions at 55 ºC in high yields. Also, this method is applicable for the preparation of diversity and oriented pyrrole derivatives.

Keywords

Stannous(II) chloride Pyrrole Diversity synthesis Hexane-2,5-dione Aqueous medium
Tejeswararao, D., & Srikanth, B. (2020). SnCl2 Catalyzed Direct Synthesis of Pyrroles under Aqueous Conditions. Asian Journal of Chemistry, 32(4), 795–802. https://doi.org/10.14233/ajchem.2020.22454
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