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Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

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Design, Synthesis, Molecular Docking and Antimicrobial Evaluation of Some Tosyl Carbamate Derivatives

https://doi.org/10.14233/ajchem.2020.22440
Panneerselvam Kalaivani
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India
Jayaraman Arikrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India
Mannuthusamy Gopalakrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram-608002, India

Corresponding Author(s) : Mannuthusamy Gopalakrishnan

mgkrishnan61@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 4 (2020): Vol 32 Issue 4, 2020

Abstract

A series of tosyl carbamates have been synthesized and screened for their antibacterial and antifungal activities. All the synthesized compounds were characterized by spectral techniques (IR, 1H, 13C NMR and mass) and elemental analysis. in silico Molecular docking method was performed to study their antimicrobial activity against the target protein 1T9U. Compound 27 showed good antibacterial activity against Gram-positive and Gram-negative bacterial strains and compound 19 showed good antifungal activity. Molecular docking results revealed that the compound 19 exhibits minimum CDOCKER energy. Tosyl carbamate derivatives having good antimicrobial activities compared to that standard and all the synthesized compounds exhibits moderate CDOCKER scores.

Keywords

Tosyl carbamates Molecular docking Protein 1T9U CDOCKER energy
Kalaivani, P., Arikrishnan, J., & Gopalakrishnan, M. (2020). Design, Synthesis, Molecular Docking and Antimicrobial Evaluation of Some Tosyl Carbamate Derivatives. Asian Journal of Chemistry, 32(4), 783–788. https://doi.org/10.14233/ajchem.2020.22440
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