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Vol. 32 No. 3 (2020): Vol 32 Issue 3

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Ultrasound Assisted Synthesis of 1,5-Disubstituted Pyrazole using Cu(I) Catalyst

https://doi.org/10.14233/ajchem.2020.22432
Ashok S. Pise
Department of Chemistry, Dada Patil Mahavidyalaya, Karjat-414402, India
Arvind S. Burungale
Department of Chemistry, S.M. Joshi College, Hadapsar, Pune-411028, India
Santosh S. Devkate
Department of Chemistry, S.M. Joshi College, Hadapsar, Pune-411028, India

Corresponding Author(s) : Arvind S. Burungale

ashokpise67@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 3 (2020): Vol 32 Issue 3

Abstract

A new efficient and convenient approach towards the synthesis of pyrazole is described. The α,β-unsaturated cyanoesters were obtained from substituted benzaldehyde and ethyl cyanoacetate by reported methods. 1,5-Disubstituted pyrazoles were synthesized from α,β-unsaturated cyanoester and phenyl hydrazine using sodium ethoxide as a base in the presence of 10 mol % Cu(I) catalyst in high yields within 75-90 min under ultrasound irradiation at 60 ºC. The reaction rate is enhanced tremendously under ultrasound irradiation as compare to conventional methods with improved yields are recorded.

Keywords

Cyanoester Cu(I) catalyst Phenyl hydrazine Pyrazole Ultrasound irradiation
Pise, A. S., Burungale, A. S., & Devkate, S. S. (2020). Ultrasound Assisted Synthesis of 1,5-Disubstituted Pyrazole using Cu(I) Catalyst. Asian Journal of Chemistry, 32(3), 575–579. https://doi.org/10.14233/ajchem.2020.22432
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