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Vol. 32 No. 3 (2020): Vol 32 Issue 3

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Synthesis, Characterization and Anti-inflammatory Activity of (2E)-3-(2-Bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-one

https://doi.org/10.14233/ajchem.2020.22421
Dileep Kumar M. Guruswamy
PG Department of Biotechnology, Teresian College, Mysuru-570011, India
https://orcid.org/0000-0002-7964-185X
Shankar Jayarama
PG Department of Biotechnology, Teresian College, Mysuru-570011, India
https://orcid.org/0000-0003-0452-6467

Corresponding Author(s) : Shankar Jayarama

sankkar.bio@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 3 (2020): Vol 32 Issue 3

Abstract

(2E)-3-(2-Bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-one (d1) was synthesized by the Claisen-Schmidt condensation method and characterized by 1H NMR, 13C NMR spectral studies. The anti-inflammatory activity was conducted in Swiss albino rats for paw edema model. Edema was actuated with 1 % carrageenan to every one of the animals following 1 h of the oral medicines. Paw thickness was checked at t = 1, 2, 3, 4, 5 and 24 h. Stair climbing score and motility score were surveyed at t = 24 h. Compound d1 signicant decline in paw thickness at p < 0.001 diminished by 32 % in paw thickness. The compound d1 signicantly expanded the stair climbing and motility score. This study suggested that the compound d1 exhibits remarkable anti-inflammatory activity when compared with that of the standard drug.

Keywords

Naphthalene chalcones Anti-inflammatory activity Paw edema
M. Guruswamy, D. K., & Jayarama, S. (2020). Synthesis, Characterization and Anti-inflammatory Activity of (2E)-3-(2-Bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-one. Asian Journal of Chemistry, 32(3), 561–564. https://doi.org/10.14233/ajchem.2020.22421
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