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Vol. 32 No. 2 (2020): Vol 32 Issue 2

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Biological Evolution of Titanium(IV) Complex [{(NNO)2Ti}3O3] Bearing Bidentate Heteroditopic Schiff Base Ligand: Synthesis, Structure and Biological Studies

https://doi.org/10.14233/ajchem.2020.22464
Ravi K. Kottalanka
Division of Chemistry, Department of Sciences and Humanities, Vignan′s Foundation for Science, Technology and Research, Vadlamudi- 522213, India
https://orcid.org/0000-0002-5799-6908
Eswar Pagadala
Division of Chemistry, Department of Sciences and Humanities, Vignan′s Foundation for Science, Technology and Research, Vadlamudi- 522213, India
https://orcid.org/0000-0003-2383-6700
Shiva K. Loke
Division of Chemistry, Department of Sciences and Humanities, Vignan′s Foundation for Science, Technology and Research, Vadlamudi- 522213, India
https://orcid.org/0000-0003-4423-3335
S. Rex Jeya Rajkumar
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research, Vadlamudi-522213, India
https://orcid.org/0000-0002-5760-9437
Venkatesan Srinivasadesikan
Division of Chemistry, Department of Sciences and Humanities, Vignan′s Foundation for Science, Technology and Research, Vadlamudi- 522213, India
https://orcid.org/0000-0001-9533-1299
Balajee Ramchandran
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research, Vadlamudi-522213, India

Corresponding Author(s) : Ravi K. Kottalanka

ravikottalanka@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 2 (2020): Vol 32 Issue 2

Abstract

Titanium(IV)-complex of chemical composition [{(NNO)2Ti}3O3] (2) bearing bidentate heteroditopic Schiff base [(C5H4OH)-N=CH-C4H3-NH] (L1) ligand in titanium coordination sphere was reported and its biological significance was evaluated. The in vitro cytotoxicity of L1 and 2 were evaluated by using MTT assay on cancer cell lines (MCF-7 & A549) and observed significant cytotoxicity. Further, the LDH and NO assay studies on both L1 and 2 on cancer cell lines revealed that the enhanced cytotoxicity compared to standard anticancer drug i.e. cisplatin. The DNA binding studies of tested compounds with Ct-DNA molecule by using UV-visible and fluorescence spectra and molecular docking studies revealed that moderate to good binding interactions with test molecules. Thus, the present work contributes and implies the biological significance of Ti-complex (2) and the correlation between the structure and the biological activities of such Ti-complexes supported by Schiff base systems opens up opportunities for further exploitation of similar biologically active titanium systems.

Keywords

Titanium(IV) complex Bidentate heteroditopic Schiff base Biological activity DNA Binding Docking studies
Kottalanka, R. K., Pagadala, E., Loke, S. K., Jeya Rajkumar, S. R., Srinivasadesikan, V., & Ramchandran, B. (2019). Biological Evolution of Titanium(IV) Complex [{(NNO)2Ti}3O3] Bearing Bidentate Heteroditopic Schiff Base Ligand: Synthesis, Structure and Biological Studies. Asian Journal of Chemistry, 32(2), 441–450. https://doi.org/10.14233/ajchem.2020.22464
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