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Vol. 32 No. 2 (2020): Vol 32 Issue 2

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Synthesis, Characterization and Antimicrobial Activity of N-2-(4-Chlorophenyl)acetyl Derivatives of (S)-Amino Acids

https://doi.org/10.14233/ajchem.2020.22416
G. Venkateshappa
Department of Studies and Research in Chemistry, University College of Science, Tumkur University, Tumkur-572103, India
P. Raghavendra Kumar
Department of Studies and Research in Chemistry, University College of Science, Tumkur University, Tumkur-572103, India
https://orcid.org/0000-0001-6522-6148
Krishna
Department of Biotechnology, University College of Science, Tumkur University, Tumkur-572103, India

Corresponding Author(s) : P. Raghavendra Kumar

raghukp1@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 2 (2020): Vol 32 Issue 2

Abstract

This paper reports the synthesis, characterization and antibacterial activity of N-2-(4-chlorophenyl)acetyl derivatives of various (S)-amino acids such as (S)-alanine, (S)-phenylalanine, (S)-leucine, (S)-methionine, (S)-proline and (S)-tryptophane. These compounds have been successfully synthesized and their structures were confirmed by 1H NMR and 13C NMR and FT-IR spectroscopy. The antimicrobial activity of these six (S)-amino acids derivatives have been evaluated by the agar well diffusion method against pathogens both Gram-positive (S. aureus) and Gram-negative (K. aerogenes, E. coli and P. desmolyticumas) bacteria and fungi (A. flavus and C. albicans). All these compounds have shown mild to moderate antimicrobial activity.

Keywords

Amino acid N-2-(4-Chlorophenyl)acetyl chloride Antibacterial activity Antifungal activity
Venkateshappa, G., Kumar, P. R., & Krishna, . (2019). Synthesis, Characterization and Antimicrobial Activity of N-2-(4-Chlorophenyl)acetyl Derivatives of (S)-Amino Acids. Asian Journal of Chemistry, 32(2), 381–384. https://doi.org/10.14233/ajchem.2020.22416
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